1qjd: Difference between revisions
New page: left|200px<br /> <applet load="1qjd" size="450" color="white" frame="true" align="right" spinBox="true" caption="1qjd, resolution 1.80Å" /> '''FLAVOCYTOCHROME C3 ... |
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==About this Structure== | ==About this Structure== | ||
1QJD is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Shewanella_frigidimarina Shewanella frigidimarina]] with NA, HEC, FAD, TEO and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1QJD OCA]]. | 1QJD is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Shewanella_frigidimarina Shewanella frigidimarina]] with NA, HEC, FAD, TEO and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: SBS. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1QJD OCA]]. | ||
==Reference== | ==Reference== | ||
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[[Category: respiratory fumarate reductase]] | [[Category: respiratory fumarate reductase]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:32:11 2007'' | ||
Revision as of 13:27, 30 October 2007
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FLAVOCYTOCHROME C3 FROM SHEWANELLA FRIGIDIMARINA
OverviewOverview
The 1.8 A resolution crystal structure of the tetraheme flavocytochrome, c3, Fcc3, provides the first mechanistic insight into respiratory fumarate, reductases or succinate dehydrogenases. The multi-redox center, three-domain protein shows a 40 A long 'molecular wire' allowing rapid, conduction of electrons through a new type of cytochrome domain onto the, active site flavin, driving the reduction of fumarate to succinate. In, this structure a malate-like molecule is trapped in the enzyme active, site. The interactions between this molecule and the enzyme suggest a, clear mechanism for fumarate reduction in which the substrate is polarized, and twisted, facilitating hydride transfer from the reduced flavin and, subsequent proton transfer. The enzyme active site in the oxidized form is, ... [(full description)]
About this StructureAbout this Structure
1QJD is a [Single protein] structure of sequence from [Shewanella frigidimarina] with NA, HEC, FAD, TEO and GOL as [ligands]. Structure known Active Site: SBS. Full crystallographic information is available from [OCA].
ReferenceReference
Structural and mechanistic mapping of a unique fumarate reductase., Taylor P, Pealing SL, Reid GA, Chapman SK, Walkinshaw MD, Nat Struct Biol. 1999 Dec;6(12):1108-12. PMID:10581550
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