Antithrombin: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

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 {{STRUCTURE_1tb6|  PDB=1tb6  | SIZE=400| SCENE= |right|CAPTION=Antithrombin complex with thrombin and heparin polysaccharide, [[1tb6]] }}
-'''Antithrombin''' (AT) inactivates several enzymes of the coagulation cycle.  A-AT contains 4 occupied glycosylation sites and is found in blood palsma. B-AT contains only 3 occupied glycosylation sites.  AT-I refers to the absorption of thrombin to fibrin; AT-II and heparin interfere with the interactin of thrombin and fibrinogen; AT-III inactivates thrombin in plasma; AT-IV becomes activated during blood coagulation.
+'''Antithrombin''' (AT) inactivates several enzymes of the coagulation cycle.  α-AT contains 4 occupied glycosylation sites and is found in blood palsma. β-AT contains only 3 occupied glycosylation sites.  AT-I refers to the absorption of thrombin to fibrin; AT-II and heparin interfere with the interactin of thrombin and fibrinogen; AT-III inactivates thrombin in plasma; AT-IV becomes activated during blood coagulation.
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 [[1ant]], [[2ant]] – hAT – human
-[[1e05]] - ha-AT-III
+[[1e05]] - hα-AT-III
-[[1e04]] – hb-AT-III
+[[1e04]] – hβ-AT-III
 [[1ath]], [[2znh]] – hAT-III
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 [[1azx]], [[1nq9]], [[3evj]] – hAT + heparin pentasaccharide
-[[1e03]] – ha-AT-III + heparin pentasaccharide
+[[1e03]] – hα-AT-III + heparin pentasaccharide
 [[1dzh]] - hAT-III (mutant) + fluorescein