2bz0: Difference between revisions
New page: left|200px<br /> <applet load="2bz0" size="450" color="white" frame="true" align="right" spinBox="true" caption="2bz0, resolution 2.60Å" /> '''CRYSTAL STRUCTURE O... |
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==About this Structure== | ==About this Structure== | ||
2BZ0 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]] with ZN, MG and G2P as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.4.25 3.5.4.25]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BZ0 OCA]]. | 2BZ0 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]] with ZN, MG and G2P as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/GTP_cyclohydrolase_II GTP cyclohydrolase II]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.4.25 3.5.4.25]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BZ0 OCA]]. | ||
==Reference== | ==Reference== | ||
GTP cyclohydrolase II structure and mechanism., Ren J, Kotaka M, Lockyer M, Lamb HK, Hawkins AR, Stammers DK, J Biol Chem. 2005 Nov 4;280(44):36912-9. Epub 2005 Aug 22. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16115872 16115872] | GTP cyclohydrolase II structure and mechanism., Ren J, Kotaka M, Lockyer M, Lamb HK, Hawkins AR, Stammers DK, J Biol Chem. 2005 Nov 4;280(44):36912-9. Epub 2005 Aug 22. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16115872 16115872] | ||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: GTP cyclohydrolase II]] | |||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Hawkins, A.R.]] | [[Category: Hawkins, A.R.]] | ||
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[[Category: riboflavin biosynthesis]] | [[Category: riboflavin biosynthesis]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:30:44 2007'' | ||
Revision as of 13:26, 30 October 2007
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CRYSTAL STRUCTURE OF E. COLI GTP CYCLOHYDROLASE II IN COMPLEX WITH GTP ANALOGUE, GMPCPP, AND ZINC
OverviewOverview
GTP cyclohydrolase II converts GTP to, 2,5-diamino-6-beta-ribosyl-4(3H)-pyrimidinone 5'-phosphate, formate and, pyrophosphate, the first step in riboflavin biosynthesis. The essential, role of riboflavin in metabolism and the absence of GTP cyclohydrolase II, in higher eukaryotes makes it a potential novel selective antimicrobial, drug target. GTP cyclohydrolase II catalyzes a distinctive overall, reaction from GTP cyclohydrolase I; the latter converts GTP to, dihydroneopterin triphosphate, utilized in folate and tetrahydrobiopterin, biosynthesis. The structure of GTP cyclohydrolase II determined at 1.54-A, resolution reveals both a different protein fold to GTP cyclohydrolase I, and distinctive molecular recognition determinants for GTP; although in, both enzymes there is a bound ... [(full description)]
About this StructureAbout this Structure
2BZ0 is a [Single protein] structure of sequence from [Escherichia coli] with ZN, MG and G2P as [ligands]. Active as [GTP cyclohydrolase II], with EC number [3.5.4.25]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
ReferenceReference
GTP cyclohydrolase II structure and mechanism., Ren J, Kotaka M, Lockyer M, Lamb HK, Hawkins AR, Stammers DK, J Biol Chem. 2005 Nov 4;280(44):36912-9. Epub 2005 Aug 22. PMID:16115872
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