Ficolin: Difference between revisions
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{{STRUCTURE_2j0h| PDB=2j0h | SIZE=400| SCENE= |right|CAPTION=Human L-ficolin binding domain complex with galactosamine, [[2j0h]] }} | {{STRUCTURE_2j0h| PDB=2j0h | SIZE=400| SCENE= |right|CAPTION=Human L-ficolin binding domain complex with galactosamine and Ca+2 ion, [[2j0h]] }} | ||
'''Ficolin''' (Fic) are defense proteins which belong to the innate immune system and recognize carbohydrate molecules. 3 ficolins were identified in humans L-Fic, H-Fic and M-Fic. | '''Ficolin''' (Fic) are defense proteins which belong to the innate immune system and recognize carbohydrate molecules. 3 ficolins were identified in humans L-Fic, H-Fic and M-Fic. | ||
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== 3D Structures of Ficoln == | == 3D Structures of Ficoln == | ||
===H-ficolin=== | |||
[[2j64]] - hH-Fic binding domain - human<br /> | |||
[[2j5z]] - hH-Fic binding domain + galactose<br /> | |||
[[2j60]] - hH-Fic binding domain + fucose<br /> | |||
[[2j61]] - hH-Fic binding domain + acetyl-glucosamine<br /> | |||
===L-ficolin=== | |||
[[2j3g]] - hL-Fic binding domain<br /> | |||
[[2j0g]] – hL-Fic binding domain + N-acetyl-mannosamine<br /> | |||
[[2j0h]] - hL-Fic binding domain + acetylcholine<br /> | |||
[[2j0y]] - hL-Fic binding domain + glucan<br /> | |||
[[2j1g]], [[2j2p]] - hL-Fic binding domain + acetylcysteine<br /> | |||
[[2j3f]] - hL-Fic binding domain + galactosamine<br /> | |||
[[2j3o]] - hL-Fic binding domain + acetyl-glucosamine<br /> | |||
[[2j3u]] - hL-Fic binding domain + galactose<br /> | |||
===M-ficolin=== | |||
[[2d39]] – hM-Fic fibrinogen-like domain<br /> | |||
[[2wnp]] - hM-Fic fibrinogen-like domain (mutant) <br /> | |||
[[2jhh, [[2jhm]] – hM-Fic C terminal<br /> | |||
[[2jhi]] - hL-Mic C terminal + acetyl-galactosamine<br /> | |||
[[2jhk]] - hL-Mic C terminal + acetyl-glucosamine<br /> | |||
[[2jhl]] - hL-Mic C terminal + sialic acid | |||