1e96: Difference between revisions
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[[Image:1e96.jpg|left|200px]]<br /><applet load="1e96" size=" | [[Image:1e96.jpg|left|200px]]<br /><applet load="1e96" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="1e96, resolution 2.4Å" /> | caption="1e96, resolution 2.4Å" /> | ||
'''STRUCTURE OF THE RAC/P67PHOX COMPLEX'''<br /> | '''STRUCTURE OF THE RAC/P67PHOX COMPLEX'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
1E96 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with MG and GTP as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=GTP:Gtp Binding Site For Chain A Residue 200'>GTP</scene>. Full crystallographic information is available from [http:// | 1E96 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=MG:'>MG</scene> and <scene name='pdbligand=GTP:'>GTP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=GTP:Gtp+Binding+Site+For+Chain+A+Residue+200'>GTP</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E96 OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: tpr motif]] | [[Category: tpr motif]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 09:38:22 2008'' | ||
Revision as of 10:38, 3 February 2008
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STRUCTURE OF THE RAC/P67PHOX COMPLEX
OverviewOverview
p67phox is an essential part of the NADPH oxidase, a multiprotein enzyme, complex that produces superoxide ions in response to microbial infection., Binding of the small GTPase Rac to p67phox is a key step in the assembly, of the active enzyme complex. The structure of Rac.GTP bound to the, N-terminal TPR (tetratricopeptide repeat) domain of p67phox reveals a, novel mode of Rho family/effector interaction and explains the basis of, GTPase specificity. Complex formation is largely mediated by an insertion, between two TPR motifs, suggesting an unsuspected versatility of TPR, domains in target recognition and in their more general role as scaffolds, for the assembly of multiprotein complexes.
DiseaseDisease
Known disease associated with this structure: Chronic granulomatous disease due to deficiency of NCF-2 OMIM:[608515]
About this StructureAbout this Structure
1E96 is a Protein complex structure of sequences from Homo sapiens with and as ligands. Known structural/functional Site: . Full crystallographic information is available from OCA.
ReferenceReference
Structure of the TPR domain of p67phox in complex with Rac.GTP., Lapouge K, Smith SJ, Walker PA, Gamblin SJ, Smerdon SJ, Rittinger K, Mol Cell. 2000 Oct;6(4):899-907. PMID:11090627
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