1cqe: Difference between revisions
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[[Image:1cqe.gif|left|200px]]<br /><applet load="1cqe" size=" | [[Image:1cqe.gif|left|200px]]<br /><applet load="1cqe" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="1cqe, resolution 3.1Å" /> | caption="1cqe, resolution 3.1Å" /> | ||
'''PROSTAGLANDIN H2 SYNTHASE-1 COMPLEX WITH FLURBIPROFEN'''<br /> | '''PROSTAGLANDIN H2 SYNTHASE-1 COMPLEX WITH FLURBIPROFEN'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
1CQE is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Ovis_aries Ovis aries] with BOG, HEM and FLP as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Prostaglandin-endoperoxide_synthase Prostaglandin-endoperoxide synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.99.1 1.14.99.1] Known structural/functional Sites: <scene name='pdbsite=COA:Hydrophobic Channel Responsible For Cycloogenase Activity'>COA</scene>, <scene name='pdbsite=COB:Hydrophobic Channel Responsible For Cycloogenase Activity'>COB</scene>, <scene name='pdbsite=POA:Heme Pocket Responsible For Peroxidase Activity'>POA</scene> and <scene name='pdbsite=POB:Heme Pocket Responsible For Peroxidase Activity'>POB</scene>. Full crystallographic information is available from [http:// | 1CQE is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Ovis_aries Ovis aries] with <scene name='pdbligand=BOG:'>BOG</scene>, <scene name='pdbligand=HEM:'>HEM</scene> and <scene name='pdbligand=FLP:'>FLP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Prostaglandin-endoperoxide_synthase Prostaglandin-endoperoxide synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.99.1 1.14.99.1] Known structural/functional Sites: <scene name='pdbsite=COA:Hydrophobic+Channel+Responsible+For+Cycloogenase+Activity'>COA</scene>, <scene name='pdbsite=COB:Hydrophobic+Channel+Responsible+For+Cycloogenase+Activity'>COB</scene>, <scene name='pdbsite=POA:Heme+Pocket+Responsible+For+Peroxidase+Activity'>POA</scene> and <scene name='pdbsite=POB:Heme+Pocket+Responsible+For+Peroxidase+Activity'>POB</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CQE OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: peroxidase]] | [[Category: peroxidase]] | ||
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Revision as of 10:34, 3 February 2008
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PROSTAGLANDIN H2 SYNTHASE-1 COMPLEX WITH FLURBIPROFEN
OverviewOverview
The three-dimensional structure of prostaglandin H2 synthase-1, an, integral membrane protein, has been determined at 3.5 A resolution by, X-ray crystallography. This bifunctional enzyme comprises three, independent folding units: an epidermal growth factor domain, a, membrane-binding motif and an enzymatic domain. Two adjacent but spatially, distinct active sites were found for its haem-dependent peroxidase and, cyclooxygenase activities. The cyclooxygenase active site is created by a, long, hydrophobic channel that is the site of non-steroidal, anti-inflammatory drug binding. The conformation of the membrane-binding, motif strongly suggests that the enzyme integrates into only one leaflet, of the lipid bilayer and is thus a monotopic membrane protein.
About this StructureAbout this Structure
1CQE is a Single protein structure of sequence from Ovis aries with , and as ligands. Active as Prostaglandin-endoperoxide synthase, with EC number 1.14.99.1 Known structural/functional Sites: , , and . Full crystallographic information is available from OCA.
ReferenceReference
The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1., Picot D, Loll PJ, Garavito RM, Nature. 1994 Jan 20;367(6460):243-9. PMID:8121489
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