1blx: Difference between revisions
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[[Image:1blx.gif|left|200px]]<br /><applet load="1blx" size=" | [[Image:1blx.gif|left|200px]]<br /><applet load="1blx" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="1blx, resolution 1.9Å" /> | caption="1blx, resolution 1.9Å" /> | ||
'''P19INK4D/CDK6 COMPLEX'''<br /> | '''P19INK4D/CDK6 COMPLEX'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
1BLX is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with CA as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=CAB:Ca Binding Site'>CAB</scene>. Full crystallographic information is available from [http:// | 1BLX is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=CAB:Ca+Binding+Site'>CAB</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BLX OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: inhibitor protein]] | [[Category: inhibitor protein]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 09:33:19 2008'' | ||
Revision as of 10:33, 3 February 2008
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P19INK4D/CDK6 COMPLEX
OverviewOverview
The crystal structure of the cyclin D-dependent kinase Cdk6 bound to the, p19 INK4d protein has been determined at 1.9 A resolution. The results, provide the first structural information for a cyclin D-dependent protein, kinase and show how the INK4 family of CDK inhibitors bind. The structure, indicates that the conformational changes induced by p19INK4d inhibit both, productive binding of ATP and the cyclin-induced rearrangement of the, kinase from an inactive to an active conformation. The structure also, shows how binding of an INK4 inhibitor would prevent binding of p27Kip1, resulting in its redistribution to other CDKs. Identification of the, critical residues involved in the interaction explains how mutations in, Cdk4 and p16INK4a result in loss of kinase inhibition and cancer.
About this StructureAbout this Structure
1BLX is a Protein complex structure of sequences from Homo sapiens and Mus musculus with as ligand. Known structural/functional Site: . Full crystallographic information is available from OCA.
ReferenceReference
Crystal structure of the complex of the cyclin D-dependent kinase Cdk6 bound to the cell-cycle inhibitor p19INK4d., Brotherton DH, Dhanaraj V, Wick S, Brizuela L, Domaille PJ, Volyanik E, Xu X, Parisini E, Smith BO, Archer SJ, Serrano M, Brenner SL, Blundell TL, Laue ED, Nature. 1998 Sep 17;395(6699):244-50. PMID:9751051
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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCA- Pages with broken file links
- Homo sapiens
- Mus musculus
- Protein complex
- Archer, S.J.
- Blundell, T.L.
- Brenner, S.L.
- Brizuela, L.
- Brotherton, D.H.
- Dhanaraj, V.
- Domaille, P.J.
- Laue, E.D.
- Parisini, E.
- Serrano, M.
- Smith, B.O.
- Volyanik, E.
- Wick, S.
- Xu, X.
- CA
- Alpha/beta
- Cell cycle control
- Complex (inhibitor protein/kinase)
- Cyclin-dependent kinase
- Inhibitor protein