1adw: Difference between revisions
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[[Image:1adw.gif|left|200px]]<br /><applet load="1adw" size=" | [[Image:1adw.gif|left|200px]]<br /><applet load="1adw" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="1adw, resolution 2.5Å" /> | caption="1adw, resolution 2.5Å" /> | ||
'''PSEUDOAZURIN'''<br /> | '''PSEUDOAZURIN'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
1ADW is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Paracoccus_pantotrophus Paracoccus pantotrophus] with CU as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Sites: <scene name='pdbsite=CUA:Cu Binding Site - HIS 40, CYS 78, HIS 81, And MET 86 Are ...'>CUA</scene> and <scene name='pdbsite=CUB:Cu Binding Site - HIS 40, CYS 78, HIS 81, And MET 86 Are ...'>CUB</scene>. Full crystallographic information is available from [http:// | 1ADW is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Paracoccus_pantotrophus Paracoccus pantotrophus] with <scene name='pdbligand=CU:'>CU</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Sites: <scene name='pdbsite=CUA:Cu+Binding+Site+-+HIS+40,+CYS+78,+HIS+81,+And+MET+86+Are+...'>CUA</scene> and <scene name='pdbsite=CUB:Cu+Binding+Site+-+HIS+40,+CYS+78,+HIS+81,+And+MET+86+Are+...'>CUB</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ADW OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: electron transport]] | [[Category: electron transport]] | ||
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Revision as of 10:29, 3 February 2008
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PSEUDOAZURIN
OverviewOverview
The structure of pseudoazurin from Thiosphaera pantotropha has been, determined and compared to structures of both soluble and membrane-bound, periplasmic redox proteins. The results show a matching set of unipolar, but promiscuous, docking motifs based on a positive hydrophobic surface, patch on the electron shuttle proteins pseudoazurin and cytochrome c550, and a negative hydrophobic patch on the surface of their known redox, partners. The observed electrostatic handedness is argued to be associated, with the charge-asymmetry of the membrane-bound components of the redox, chain due to von Heijne's 'positives-inside' principle. We propose a, 'positives-in-between' rule for electron shuttle proteins, and expect a, negative hydrophobic patch to be present on both the highest and lowest, redox potential species in a series of electron carriers.
About this StructureAbout this Structure
1ADW is a Single protein structure of sequence from Paracoccus pantotrophus with as ligand. Known structural/functional Sites: and . Full crystallographic information is available from OCA.
ReferenceReference
Pseudospecific docking surfaces on electron transfer proteins as illustrated by pseudoazurin, cytochrome c550 and cytochrome cd1 nitrite reductase., Williams PA, Fulop V, Leung YC, Chan C, Moir JW, Howlett G, Ferguson SJ, Radford SE, Hajdu J, Nat Struct Biol. 1995 Nov;2(11):975-82. PMID:7583671
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