1a7u: Difference between revisions
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[[Image:1a7u.jpg|left|200px]]<br /><applet load="1a7u" size=" | [[Image:1a7u.jpg|left|200px]]<br /><applet load="1a7u" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="1a7u, resolution 1.75Å" /> | caption="1a7u, resolution 1.75Å" /> | ||
'''CHLOROPEROXIDASE T'''<br /> | '''CHLOROPEROXIDASE T'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
1A7U is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_aureofaciens Streptomyces aureofaciens]. Active as [http://en.wikipedia.org/wiki/Chloride_peroxidase Chloride peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.10 1.11.1.10] Known structural/functional Sites: <scene name='pdbsite=CTA:Catalytic Triad'>CTA</scene> and <scene name='pdbsite=CTB:Catalytic Triad'>CTB</scene>. Full crystallographic information is available from [http:// | 1A7U is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_aureofaciens Streptomyces aureofaciens]. Active as [http://en.wikipedia.org/wiki/Chloride_peroxidase Chloride peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.10 1.11.1.10] Known structural/functional Sites: <scene name='pdbsite=CTA:Catalytic+Triad'>CTA</scene> and <scene name='pdbsite=CTB:Catalytic+Triad'>CTB</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A7U OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: peroxidase]] | [[Category: peroxidase]] | ||
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Revision as of 10:29, 3 February 2008
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CHLOROPEROXIDASE T
OverviewOverview
The structures of cofactor-free haloperoxidases from Streptomyces, aureofaciens, Streptomyces lividans, and Pseudomonas fluorescens have been, determined at resolutions between 1.9 A and 1.5 A. The structures of two, enzymes complexed with benzoate or propionate identify the binding site, for the organic acids which are required for the haloperoxidase activity., Based on these complexes and on the structure of an inactive variant, a, reaction mechanism is proposed for the halogenation reaction with, peroxoacid and hypohalous acid as reaction intermediates. Comparison of, the structures suggests that a specific halide binding site is absent in, the enzymes but that hydrophobic organic compounds may fit into the active, site pocket for halogenation at preferential sites.
About this StructureAbout this Structure
1A7U is a Single protein structure of sequence from Streptomyces aureofaciens. Active as Chloride peroxidase, with EC number 1.11.1.10 Known structural/functional Sites: and . Full crystallographic information is available from OCA.
ReferenceReference
Structural investigation of the cofactor-free chloroperoxidases., Hofmann B, Tolzer S, Pelletier I, Altenbuchner J, van Pee KH, Hecht HJ, J Mol Biol. 1998 Jun 19;279(4):889-900. PMID:9642069
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