3rtm: Difference between revisions
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[[Image:3rtm.jpg|left|200px]] | |||
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{{STRUCTURE_3rtm| PDB=3rtm | SCENE= }} | |||
===Structure of Bace-1 (Beta-Secretase) in Complex with 3-(2-Aminoquinolin-3-yl)-N-cyclohexyl-N-methylpropanamide=== | |||
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{{ABSTRACT_PUBMED_21707077}} | |||
==About this Structure== | |||
[[3rtm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RTM OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:021707077</ref><references group="xtra"/> | |||
[[Category: Homo sapiens]] | |||
[[Category: Memapsin 2]] | |||
[[Category: Sickmier, E A.]] | |||
[[Category: Aspartyl protease]] | |||
[[Category: Hydrolase-hydrolase inhibitor complex]] | |||
Revision as of 09:46, 31 August 2011
Structure of Bace-1 (Beta-Secretase) in Complex with 3-(2-Aminoquinolin-3-yl)-N-cyclohexyl-N-methylpropanamideStructure of Bace-1 (Beta-Secretase) in Complex with 3-(2-Aminoquinolin-3-yl)-N-cyclohexyl-N-methylpropanamide
Template:ABSTRACT PUBMED 21707077
About this StructureAbout this Structure
3rtm is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Cheng Y, Judd TC, Bartberger MD, Brown J, Chen K, Fremeau RT, Hickman D, Hitchcock SA, Jordan B, Li V, Lopez P, Louie SW, Luo Y, Michelsen K, Nixey T, Powers TS, Rattan C, Sickmier EA, St Jean DJ, Wahl RC, Wen PH, Wood S. From Fragment Screening to In Vivo Efficacy: Optimization of a Series of 2-Aminoquinolines as Potent Inhibitors of Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1). J Med Chem. 2011 Aug 25;54(16):5836-57. Epub 2011 Jul 29. PMID:21707077 doi:10.1021/jm200544q