1a0b: Difference between revisions
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[[Image:1a0b.jpg|left|200px]]<br /><applet load="1a0b" size=" | [[Image:1a0b.jpg|left|200px]]<br /><applet load="1a0b" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="1a0b, resolution 2.06Å" /> | caption="1a0b, resolution 2.06Å" /> | ||
'''HISTIDINE-CONTAINING PHOSPHOTRANSFER DOMAIN OF ARCB FROM ESCHERICHIA COLI'''<br /> | '''HISTIDINE-CONTAINING PHOSPHOTRANSFER DOMAIN OF ARCB FROM ESCHERICHIA COLI'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
1A0B is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with ZN as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Sites: <scene name='pdbsite=PHB:Phosphorylation Site'>PHB</scene> and <scene name='pdbsite=ZNB:Zn Binding Site'>ZNB</scene>. Full crystallographic information is available from [http:// | 1A0B is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Sites: <scene name='pdbsite=PHB:Phosphorylation+Site'>PHB</scene> and <scene name='pdbsite=ZNB:Zn+Binding+Site'>ZNB</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A0B OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: two-component system]] | [[Category: two-component system]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 09:28:32 2008'' | ||
Revision as of 10:28, 3 February 2008
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HISTIDINE-CONTAINING PHOSPHOTRANSFER DOMAIN OF ARCB FROM ESCHERICHIA COLI
OverviewOverview
The histidine-containing phosphotransfer (HPt) domain is a novel protein, module with an active histidine residue that mediates phosphotransfer, reactions in the two-component signaling systems. A multistep phosphorelay, involving the HPt domain has been suggested for these signaling pathways., The crystal structure of the HPt domain of the anaerobic sensor kinase, ArcB has been determined at 2.06 A resolution. The domain consists of six, alpha helices containing a four-helix bundle-folding. The pattern of, sequence similarity of the HPt domains of ArcB and components in other, signaling systems can be interpreted in light of the three-dimensional, structure and supports the conclusion that the HPt domains have a common, structural motif both in prokaryotes and eukaryotes.
About this StructureAbout this Structure
1A0B is a Single protein structure of sequence from Escherichia coli with as ligand. Known structural/functional Sites: and . Full crystallographic information is available from OCA.
ReferenceReference
Insights into multistep phosphorelay from the crystal structure of the C-terminal HPt domain of ArcB., Kato M, Mizuno T, Shimizu T, Hakoshima T, Cell. 1997 Mar 7;88(5):717-23. PMID:9054511
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