Aricept Complexed with Acetylcholinesterase: Difference between revisions
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==Results== | ==Results== | ||
The X-ray structure of the E2020-''Tc''AChE complex shows that E2020 has a <scene name='1eve/E2020_close_up_with_84_279/3'>unique orientation</scene>, along the active-site gorge, extending from the anionic subsite (<scene name='1eve/E2020_close_up_with_84lbld/1'>W84</scene>) of the, active site, at the bottom, to the peripheral anionic site (<scene name='1eve/E2020_close_up_with_84_279lbld/1'>near W279</scene>), at the top, via aromatic stacking interactions with conserved aromatic acid residues. E2020 does not, however, interact directly with either the catalytic triad, or the 'oxyanion hole', but only <scene name='1eve/E20_interactionshown/2'>indirectly via solvent molecules</scene>. | The X-ray structure of the E2020-''Tc''AChE complex shows that E2020 has a <scene name='1eve/E2020_close_up_with_84_279/3'>unique orientation</scene>, along the active-site gorge, extending from the anionic subsite (<scene name='1eve/E2020_close_up_with_84lbld/1'>W84</scene>) of the, active site, at the bottom, to the peripheral anionic site (<scene name='1eve/E2020_close_up_with_84_279lbld/1'>near W279</scene>), at the top, via aromatic stacking interactions with conserved aromatic acid residues. E2020 does not, however, interact directly with either the catalytic triad, or the 'oxyanion hole', but only <scene name='1eve/E20_interactionshown/2'>indirectly via solvent molecules</scene>. | ||
[[Image:E2020_interactins_in_AChE_gorge.jpg]] | |||
==Conclusions== | ==Conclusions== | ||