Aricept Complexed with Acetylcholinesterase: Difference between revisions

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OCA, Joel L. Sussman, Eran Hodis, Wayne Decatur, Jaime Prilusky, Alexander Berchansky, David Canner, Lucie Kolarova, Pham Ngoc Phuong, Angel Herraez, Michal Harel

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 ==Background==
+Several cholinesterase inhibitors are either being utilized, for symptomatic treatment of Alzheimer's disease or are in advanced, clinical trials.
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-Several cholinesterase inhibitors are either being utilized, for symptomatic treatment of Alzheimer's disease or are in advanced, clinical trials. '''E2020''', marketed as '''Aricept''', is a member of a large family, of N-benzylpiperidine-based [[acetylcholinesterase]] (AChE) inhibitors, developed, synthesized and evaluated by the Eisai Company in Japan. These, inhibitors were designed on the basis of QSAR studies, prior to, elucidation of the 3D structure of ''Torpedo californica'' AChE, (''Tc''AChE). It significantly enhances performance in animal models of, cholinergic hypofunction and has a high affinity for AChE, binding to both, electric eel and mouse AChE in the nanomolar range.
+'''E2020''', marketed as '''Aricept''', is a member of a large family, of N-benzylpiperidine-based [[acetylcholinesterase]] (AChE) inhibitors, developed, synthesized and evaluated by the Eisai Company in Japan. These, inhibitors were designed on the basis of QSAR studies, prior to, elucidation of the 3D structure of ''Torpedo californica'' AChE, (''Tc''AChE). It significantly enhances performance in animal models of, cholinergic hypofunction and has a high affinity for AChE, binding to both, electric eel and mouse AChE in the nanomolar range.
 ==Results==