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Ribose-5-phosphate isomerase: Difference between revisions

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{{STRUCTURE_3enw|  PDB=3enw  | SIZE=400| SCENE= |right|CAPTION=Ribose-5-phosphate isomerase A complex with ribulose-5-phosphate, [[3enw]] }}
{{STRUCTURE_3enw|  PDB=3enw  | SIZE=400| SCENE= |right|CAPTION=Ribose-5-phosphate isomerase A complex with ribulose-5-phosphate, [[3enw]] }}


{{STRUCTURE_3enw|  PDB=3enw  |  SCENE= }}
 
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Ribose 5-Phosphate Isomerase plays a huge role in producing nucleotides and cofactors from ribose 5-phosphate in the pentose phosphate pathway and calvin cycle. Since this enzyme plays a major role in both eukaryotic and prokaryotic organisms it is a valuable enzyme and implies that RpiA subfamilies have a significant evolutionary origin<ref name="rpi6">PMID:19214439</ref>.
Ribose 5-Phosphate Isomerase plays a huge role in producing nucleotides and cofactors from ribose 5-phosphate in the pentose phosphate pathway and calvin cycle. Since this enzyme plays a major role in both eukaryotic and prokaryotic organisms it is a valuable enzyme and implies that RpiA subfamilies have a significant evolutionary origin<ref name="rpi6">PMID:19214439</ref>.


==3D structures of ribose-5-phosphate isomerase==
[[1xtz]] – Rpi – yeast<br />
[[1lk5]] – PhRpi – Pyrococcus horikoshii<br />
[[1lk7]] - PhRpi + phosphono-erythronate<br />
===Ribose-5-phosphate isomerase A===
[[3l7o]] – Rpi A – Streptococcus mutans<br />
[[3kwm]] – Rpi A – Francisella tularensis<br />
[[3ixq]] – Rpi A – Methanocaldococcus jannaschii<br />
[[3enq]] – VvRpi A – Vibrio vulnificus<br />
[[3hhe]] – Rpi A – Bartonella henselae<br />
[[1m0s]] – Rpi A – Haemophilus influenzae<br />
[[3env]] - VvRpi A + arabinofuranose-5-phosphate<br />
[[3enw]] - VvRpi A + ribulose-5-phosphate<br />
===Ribose-5-phosphate isomerase B===


[[3he8]] - CtRpi B – Clostridium thermocellum<br />
[[2vvr]] – Rpi B – Escherichia coli<br />
[[1o1x]] – Rpi B – Thermotoga maritima<br />
[[3ph3]] – CtRpi B + ribose <br />
[[3ph4]] - CtRpi B + allose<br />
[[3hee]] - CtRpi B + ribose-5-phosphate<br />
[[2vvo]] – MtRpi B + allose-6-phosphate– Mycobacterium tuberculosis<br />
[[2vvp]] - MtRpi B + ribulose-6-phosphate + phosphono-ribose + phosphonooxy pentanoic acid<br />
[[2vvq]] - MtRpi B + phosphono-ribose + phosphonooxy pentanoic acid<br />
[[2bes]] - MtRpi B + phosphono-erythronohydroxamic acid<br />
[[2bet]] - MtRpi B + phosphono-erythronate<br />


==References==
==References==

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Andrea Gorrell, Michal Harel, Alexander Berchansky, Jaime Prilusky
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