1h8f: Difference between revisions
New page: left|200px<br /> <applet load="1h8f" size="450" color="white" frame="true" align="right" spinBox="true" caption="1h8f, resolution 2.80Å" /> '''GLYCOGEN SYNTHASE K... |
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==About this Structure== | ==About this Structure== | ||
1H8F is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with EPE as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.37 2.7.1.37]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1H8F OCA]]. | 1H8F is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with EPE as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/Transferred_entry:_2.7.11.1 Transferred entry: 2.7.11.1]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.37 2.7.1.37]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1H8F OCA]]. | ||
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Transferred entry: 2.7.11.1]] | |||
[[Category: Dajani, R.]] | [[Category: Dajani, R.]] | ||
[[Category: Pearl, L.H.]] | [[Category: Pearl, L.H.]] | ||
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[[Category: kinase]] | [[Category: kinase]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:23:27 2007'' | ||
Revision as of 13:18, 30 October 2007
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GLYCOGEN SYNTHASE KINASE 3 BETA.
OverviewOverview
Glycogen synthase kinase 3 beta (GSK3 beta) plays a key role in insulin, and Wnt signaling, phosphorylating downstream targets by default, and, becoming inhibited following the extracellular signaling event. The, crystal structure of human GSK3 beta shows a catalytically active, conformation in the absence of activation-segment phosphorylation, with, the sulphonate of a buffer molecule bridging the activation-segment and, N-terminal domain in the same way as the phosphate group of the, activation-segment phospho-Ser/Thr in other kinases. The location of this, oxyanion binding site in the substrate binding cleft indicates direct, coupling of P+4 phosphate-primed substrate binding and catalytic, activation, explains the ability of GSK3 beta to processively, hyperphosphorylate substrates ... [(full description)]
About this StructureAbout this Structure
1H8F is a [Single protein] structure of sequence from [Homo sapiens] with EPE as [ligand]. Active as [Transferred entry: 2.7.11.1], with EC number [2.7.1.37]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
ReferenceReference
Crystal structure of glycogen synthase kinase 3 beta: structural basis for phosphate-primed substrate specificity and autoinhibition., Dajani R, Fraser E, Roe SM, Young N, Good V, Dale TC, Pearl LH, Cell. 2001 Jun 15;105(6):721-32. PMID:11440715
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