Proton Channels: Difference between revisions
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==3D structures of ion channels== | |||
[[Ion channels]] | |||
==Additional Resources== | ==Additional Resources== | ||
Revision as of 14:30, 21 August 2011
The M2 protein of influenza A virus is a proton channel. Its function is essential for productive infection by the virus.
See Category:Proton_channel for a list of all proton channel structures.
In January, 2008, crystallographic and NMR structures were published side by side in Nature for the transmembrane domains of the M2 protein: 3bkd to 2rlf. The former appeared to be in an open conformation blocked by amantadine, while the latter appeared to be in a closed conformation stabilized by rimantadine. (Neither drug is shown in the morph at right.)
At right is a linear-interpolation morph between 3BKD and 2RLF, showing the proposed opening and closing of this channel.
In addition to watching the animation as alpha-helical ribbons, it is useful to watch it . Be sure to rotate the molecule with your mouse to watch the animation from different perspectives!
are believed to be crucial for pH-dependent gating. (The apparent collapse and re-expansion of their sidechains is an artifact due to the linear interpolation method of morphing.) Here are His and Trp .
To be explained in a later revision, along with new scenes: Morph from Yale
3D structures of ion channels3D structures of ion channels
Additional ResourcesAdditional Resources
For additional information, see: Influenza
For additional information, see: Membrane Channels & Pumps
Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
Eric Martz, Eran Hodis, David Canner, Jaime Prilusky, Michal Harel, Alexander Berchansky, Joel L. SussmanCitation: Martz E, Hodis E, Canner D, Prilusky J, Harel M, 2011, "Proton Channels",