Proton Channels: Difference between revisions
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<applet load='3bkd2rlf.pdb' size='500' frame='true' align='right' scene='Proton_Channels/Cartoon/2' caption='Linear interpolation morph from 3bkd to model 1 of 2rlf. ' /> | <applet load='3bkd2rlf.pdb' size='500' frame='true' align='right' scene='Proton_Channels/Cartoon/2' caption='Linear interpolation morph from [[3bkd]] to model 1 of [[2rlf]]. ' /> | ||
The M2 protein of influenza A virus is a proton channel. Its function is essential for productive infection by the virus. | The M2 protein of influenza A virus is a proton channel. Its function is essential for productive infection by the virus. | ||
Revision as of 14:27, 21 August 2011
The M2 protein of influenza A virus is a proton channel. Its function is essential for productive infection by the virus.
See Category:Proton_channel for a list of all proton channel structures.
In January, 2008, crystallographic and NMR structures were published side by side in Nature for the transmembrane domains of the M2 protein: 3bkd to 2rlf. The former appeared to be in an open conformation blocked by amantadine, while the latter appeared to be in a closed conformation stabilized by rimantadine. (Neither drug is shown in the morph at right.)
At right is a linear-interpolation morph between 3BKD and 2RLF, showing the proposed opening and closing of this channel.
In addition to watching the animation as alpha-helical ribbons, it is useful to watch it . Be sure to rotate the molecule with your mouse to watch the animation from different perspectives!
are believed to be crucial for pH-dependent gating. (The apparent collapse and re-expansion of their sidechains is an artifact due to the linear interpolation method of morphing.) Here are His and Trp .
To be explained in a later revision, along with new scenes: Morph from Yale
Additional ResourcesAdditional Resources
For additional information, see: Influenza
For additional information, see: Membrane Channels & Pumps