Pepsin: Difference between revisions
Michal Harel (talk | contribs) No edit summary |
Michal Harel (talk | contribs) No edit summary |
||
| Line 53: | Line 53: | ||
Once denatured, pepsin is unable to refold to an active native state upon returning from denaturing conditions. One proposed solution for this is that pepsin formation depends on a separate prosegment (PS) domain. When returning from the denatured state, the denatured pepsin first has to bypass a large folding barrier and then in the presence of PS the native state can become thermodynamically stable. The PS therefore can catalyze pepsin folding by stabilizing the transition state <ref name="native" /> . | Once denatured, pepsin is unable to refold to an active native state upon returning from denaturing conditions. One proposed solution for this is that pepsin formation depends on a separate prosegment (PS) domain. When returning from the denatured state, the denatured pepsin first has to bypass a large folding barrier and then in the presence of PS the native state can become thermodynamically stable. The PS therefore can catalyze pepsin folding by stabilizing the transition state <ref name="native" /> . | ||
==3D structures of pepsin== | |||
===Pepsin=== | |||
[[2h6s]], [[2qzw]] – CaPep residues 59-398 – Candida albicans<br /> | |||
[[1s2b]] – SlPep - Scytalidium lignicola<br /> | |||
[[1y43]] – Pep – Aspergillus niger<br /> | |||
[[1ibq]] - Pep – Aspergillus phoenicis<br /> | |||
[[5pep]], [[3pep]], [[4pep]] – pPep – pig<br /> | |||
[[1uh7]], [[1uh8]], [[1uh9]], [[2apr]] – RcPep – Rhizopus chinensis<br /> | |||
[[1mpp]] – Pep – Rhizomucor pusillus<br /> | |||
[[1fmu]], [[1fmx]], [[2jxr]] – yPep – yeast<br /> | |||
[[1flh]], [[1psn]] – hPep – human<br /> | |||
[[3app]] – PjPep – Penicillium janthinellum<br /> | |||
[[1am5]] – Pep – Atlantic cod<br /> | |||
[[1er8]], [[3er3]], [[4er1]], [[4ape]], [[1ent]] – CpPep – Cryphonectria parasitica<br /> | |||
[[3lzy]], [[1oew]] – CpPep residues 90-419 | |||
===Pepsinogen=== | |||
[[3psg]], [[2psg]] - pPepn<br /> | |||
[[1avf]] - hPepn | |||
===Pepsin complex with inhibitor=== | |||
[[2h6t]] - CaPep residues 59-398 + pepstatin<br /> | |||
[[1eag]] - CaPep residues 59-398 + inhibitor<br /> | |||
[[2qzx]] - CaPep residues 77-418 + pepstatin<br /> | |||
[[1j71]] - Pep + peptide – Candida tropicalis<br /> | |||
[[2ifr]], [[2ifw]], [[1s2k]] – SlPep + peptide<br /> | |||
[[1yx9]] – pPep + DMSO<br /> | |||
[[1psa]] – pPep + inhibitor<br /> | |||
[[1wkr]] - Pep + pepstatin – Irpex lacteus<br /> | |||
[[4apr]], [[5apr]], [[6apr]] - RcPep + pepstatin<br /> | |||
[[3apr]] - RcPep + peptide<br /> | |||
[[2rmp]] - Pep + pepstatin – Rhizomucor miehei<br /> | |||
[[1nlu]], [[1ga1]], [[1ga4]] - PsPep + pseudo-iodotyrostatin – Pseudomonas<br /> | |||
[[1kdv]], [[1kdy]] – PsPep + peptide<br /> | |||
[[1kdz]], [[1ke1]], [[1ke2]], [[1ga6]] - PsPep + statin inhibitor<br /> | |||
[[1g0v]] – yPep + protease A inhibitor<br /> | |||
[[1fq4]], [[1fq5]], [[1fq6]], [[1fq7]], [[1fq8]] - yPep + inhibitor<br /> | |||
[[1qrp]] – hPep + peptide<br /> | |||
[[1pso]] – hPep + pepstatin<br /> | |||
[[1bxo]], [[1bxq]], [[2wea]], [[2web]], [[2wec]], [[2wed]] - PjPep + inhibitor <br /> | |||
[[1ppk]], [[1apv]], [[1apw]], [[1ppl]], [[1ppm]] – PjPep + peptide analog | |||
[[1apt]], [[1apu]] – PjPep + pepstatin<br /> | |||
[[3er5]], [[4er4]], [[5er2]], [[2er0]], [[2er6]], [[2er7]], [[2er9]], [[5er1]], [[1epl]], [[1epm]], [[1epn]], [[1epo]], [[1epp]], [[1epq]], [[1epr]] – CpPep + peptide<br /> | |||
[[4er2]] - CpPep + pepstatin<br /> | |||
[[2jji]], [[2jjj]], [[2v00]], [[1od1]], [[1oex]], [[1gvt]], [[1eed]], [[1gvu]], [[1gvv]], [[1gvw]], [[1gvx]], [[1e81]], [[1e82]], [[1e80]], [[1e5o]] – CpPep + inhibitor<br /> | |||
[[2vs2]], [[1gkt]] - CpPep + inhibitor - neutron | |||
=References= | =References= | ||