Methyl-accepting chemotaxis protein

File:1xbn.png

Crystal Structure of Methyl-accepting chemotaxis protein 1xbn

spinqualitylabelsall models PDB ID 1xbn Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
Methyl-accepting chemotaxis protein with Fe-protoporphyrin IX + O2 1xbn
Ligands:	,
Gene:	Tar4 (Thermoanaerobacter tengcongensis MB4)
Structural annotation: Resources: CATH : 1Xbna00 InterPro : Ipr004089, Ipr011644, Ipr005829, Ipr004090 Pfam : PF07700 SCOP : d1xbna_ UniProt : Q8RBX6
Functional annotation: Cellular component: membrane Biological process: signal transduction chemotaxis cGMP biosynthetic process Molecular function: guanylate cyclase activity signal transducer activity heme binding
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

Methyl-accepting chemotaxis protein (MCP) are proteins of the inner cytoplasmic face of bacterial plasma membrane with which the receptors of the outer face interact. MCP undergo reversible methylation as part of the adaptation to the signal. MCP which are NO sensing contain a heme-NO and oxygen-binding domain (H-NOX). The images at the left and at the right correspond to one representative MCP, i.e. the crystal structure of Methyl-accepting chemotaxis protein from Thermoanaerobacter tengcongensis (3hbt).

3D Structures of Methyl-accepting chemotaxis protein3D Structures of Methyl-accepting chemotaxis protein

3g67 – TmMCP – Thermotoga maritima
3g6b - TmMCP (mutant)
2ch7 – TmMCP cytoplasmic domain
3c8c - MCP N terminal – Vibrio cholerae
2qhx - MCP N terminal – Vibrio parahaemolyticus
2d4u – EcMCP ligand-binding domain (mutant) – Eschericia coli
1qu7 - EcMCP I cytoplasmic domain
1jmw - MCP II ligand-binding domain (mutant) – Salmonella typhimurium

Heme-containing MCPHeme-containing MCP

3sj5 – MCP (mutant) with Fe-protoporphyrin IX – Caldanaerobacter subterraneus
3nvr, 3nvu, 3iqb, 3eee – TtMCP N terminal (mutant) with Fe-protoporphyrin IX + O2 – Thermoanaerobacter tengcongensis
1xbn - TtMCP with Fe-protoporphyrin IX + O2
1u4h, 1u55, 1u56 - TtMCP H-NOX domain with Fe-protoporphyrin IX + O2
3lah, 3lai - TtMCP N terminal (mutant) with Fe-protoporphyrin IX + imidazole
3m0b - TtMCP N terminal with Ru-mesoporphyrin IX