Molecular Playground/Human PPCA: Difference between revisions
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<applet load='1ivy' size='[450,338]' frame='true' align='right' | <applet load='1ivy' size='[450,338]' frame='true' align='right' | ||
caption='Human Protective Protein/Cathepsin A (PPCA, | caption='Human Protective Protein/Cathepsin A (PPCA, [[1ivy]])' scene='User:Nilima_Kolli/sandbox_1/Homodimer_ppca/1'/> | ||
The dimer of <scene name='User:Nilima_Kolli/sandbox_1/PPCA/1'>PPCA</scene> is shown here in cartoon representation. The active site residues are in red with the disulphides in yellow. The catalytically competent active site is blocked by the 'blocking peptide' shown in cyan. The excision peptide shown in dark blue is positioned above the blocking peptide thus completely occluding the active site. The excision peptide is removed during processing which is assumed to result in local conformational changes that then remove the blocking peptide from occluding the active site. | The dimer of <scene name='User:Nilima_Kolli/sandbox_1/PPCA/1'>PPCA</scene> is shown here in cartoon representation. The active site residues are in red with the disulphides in yellow. The catalytically competent active site is blocked by the 'blocking peptide' shown in cyan. The excision peptide shown in dark blue is positioned above the blocking peptide thus completely occluding the active site. The excision peptide is removed during processing which is assumed to result in local conformational changes that then remove the blocking peptide from occluding the active site. | ||