Group:MUZIC:Enigma Family: Difference between revisions

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<Structure load='1RGW' size='200' frame='true' align='right' caption='NMR solution structure of PDZ domain of ZASP (PDB ID: 1RGW) [http://www.rcsb.org/pdb/explore/explore.do?structureId=1RGW]' scene='User:Adekunle_Onipe/workbench/ZASP/Zasp_pdz_domain/3' /> '''Molecular structures''' of PDZ domain(s) of the three member proteins have recently been solved. Likewise, the LIM-1 domain of Enigma Homologue protein has yielded its structure in atomic details. Structural model of all member proteins reveal canonical PDZ domain fold containing six β-strands and 2 α-helices [http://smart.embl-heidelberg.de/smart/do_annotation.pl?DOMAIN=PDZ&BLAST=DUMMY], except the '''PDZ domain of ZASP''' which ~~has~~ an extra α-helix ~~between~~ the ~~third~~ and ~~fourth~~ β-~~strand~~.

<Structure load='1RGW' size='200' frame='true' align='right' caption='NMR solution structure of PDZ domain of ZASP (PDB ID: 1RGW) [http://www.rcsb.org/pdb/explore/explore.do?structureId=1RGW]' scene='User:Adekunle_Onipe/workbench/ZASP/Zasp_pdz_domain/3' /> '''Molecular structures''' of PDZ domain(s) of the three member proteins have recently been solved. Likewise, the LIM-1 domain of Enigma Homologue protein has yielded its structure in atomic details. Structural model of all member proteins reveal canonical PDZ domain fold containing six β-strands (A-F) and 2 α-helices (A and B) [http://smart.embl-heidelberg.de/smart/do_annotation.pl?DOMAIN=PDZ&BLAST=DUMMY], except the '''PDZ domain of ZASP''' which appears to have an extra α-helix bridging the B and C β-strands; even though this extra helix, when looked at from a distal orientation, appears to be a tandem/part of the canonical B α-helix.

==Function and Interactions==

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 <Structure load='LIM1.pdb' size='200' frame='true' align='right' caption='NMR solution structure of LIM-1 domain of Enigma Homologue protein (PDB ID: 2DAR) [http://www.rcsb.org/pdb/explore/explore.do?structureId=2DAR]' scene='User:Adekunle_Onipe/workbench/Enigma_Family/Enh_lim1/2' />
-<Structure load='1RGW' size='200' frame='true' align='right' caption='NMR solution structure of PDZ domain of ZASP (PDB ID: 1RGW) [http://www.rcsb.org/pdb/explore/explore.do?structureId=1RGW]' scene='User:Adekunle_Onipe/workbench/ZASP/Zasp_pdz_domain/3' /> '''Molecular structures''' of PDZ domain(s) of the three member proteins have recently been solved. Likewise, the LIM-1 domain of Enigma Homologue protein has yielded its structure in atomic details. Structural model of all member proteins reveal canonical PDZ domain fold containing six β-strands and 2 α-helices [http://smart.embl-heidelberg.de/smart/do_annotation.pl?DOMAIN=PDZ&BLAST=DUMMY], except the '''PDZ domain of ZASP''' which has an extra α-helix between the third and fourth β-strand.
+<Structure load='1RGW' size='200' frame='true' align='right' caption='NMR solution structure of PDZ domain of ZASP (PDB ID: 1RGW) [http://www.rcsb.org/pdb/explore/explore.do?structureId=1RGW]' scene='User:Adekunle_Onipe/workbench/ZASP/Zasp_pdz_domain/3' /> '''Molecular structures''' of PDZ domain(s) of the three member proteins have recently been solved. Likewise, the LIM-1 domain of Enigma Homologue protein has yielded its structure in atomic details. Structural model of all member proteins reveal canonical PDZ domain fold containing six β-strands (A-F) and 2 α-helices (A and B) [http://smart.embl-heidelberg.de/smart/do_annotation.pl?DOMAIN=PDZ&BLAST=DUMMY], except the '''PDZ domain of ZASP''' which appears to have an extra α-helix bridging the B and C β-strands; even though this extra helix, when looked at from a distal orientation, appears to be a tandem/part of the canonical B α-helix.
 ==Function and Interactions==