Group:MUZIC:Myopodin: Difference between revisions

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== Function==

Myopodin is a dual compartment protein that redistributes between the nucleus and the cytoplasm in a differentiation-dependent and stress-induced fashion, and in addition displays actin-bundling activity <ref> PMID:11673475 </ref>.

In undifferentiated myoblasts, myopodin seems to be expressed preferentially in the nucleus and only weakly in the cytoplasm, whereas in differentiating myotubes, myopodin is incorporated into the Z-disc with no detectable nuclear expression, suggesting that myopodin may be involved in the regulation of myocyte differentiation. <ref> PMID:11673475 </ref> <ref> PMID:19360353 </ref>.

In undifferentiated myoblasts, myopodin seems to be expressed preferentially in the nucleus and only weakly in the cytoplasm, whereas in differentiating myotubes, myopodin is incorporated into the Z-disc with no detectable nuclear expression, suggesting that myopodin may be involved in the regulation of myocyte differentiation <ref> PMID:11673475 </ref> <ref> PMID:19360353 </ref>.

Myopodin has also been identified as a tumor suppressor gene that is frequently deleted in aggressive prostate cancer <ref> PMID:15111326 </ref>. Expression of myopodin protein suppresses both tumor growth and metastasis in vitro and in vivo <ref> PMID:15111326 </ref>.

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 == Function==
 Myopodin is a dual compartment protein that redistributes between the nucleus and the cytoplasm in a differentiation-dependent and stress-induced fashion, and in addition displays actin-bundling activity <ref> PMID:11673475 </ref>.
-In undifferentiated myoblasts, myopodin seems to be expressed preferentially in the nucleus and only weakly in the cytoplasm, whereas in differentiating myotubes, myopodin is incorporated into the Z-disc with no detectable nuclear expression, suggesting that myopodin may be involved in the regulation of myocyte differentiation. <ref> PMID:11673475 </ref> <ref> PMID:19360353 </ref>.
+In undifferentiated myoblasts, myopodin seems to be expressed preferentially in the nucleus and only weakly in the cytoplasm, whereas in differentiating myotubes, myopodin is incorporated into the Z-disc with no detectable nuclear expression, suggesting that myopodin may be involved in the regulation of myocyte differentiation <ref> PMID:11673475 </ref> <ref> PMID:19360353 </ref>.
 Myopodin has also been identified as a tumor suppressor gene that is frequently deleted in aggressive prostate cancer <ref> PMID:15111326 </ref>. Expression of myopodin protein suppresses both tumor growth and metastasis in vitro and in vivo <ref> PMID:15111326 </ref>.