Group:MUZIC:Myopodin: Difference between revisions

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==MYOPODIN==

The protein myopodin (encoded by the gene SYNPO2[http://www.uniprot.org/uniprot/Q9UMS6]), is also called genethonin-2, synaptopodin-2, synaptopodin-like and fesselin~~; it~~ was first described in 2001 by Weins ''et al.'', and shown to be widely expressed in striated- and smooth-muscle cells <ref> PMID:11673475 </ref> <ref> PMID:12869577 </ref>. At least six isoforms result from alternative splicing and the size of the resulting proteins varies between 76 kDa and 136 kDa; these variants show differential tissue distribution. The discrepancy between calculated molecular mass and apparent mobility in SDS-PAGE is at present still unclear, but might be due to post-translational modifications <ref> PMID:20554076 </ref> <ref> PMID:18371299 </ref> <ref> PMID:11696420</ref> <ref> PMID:12917631 </ref> <ref> PMID:18588515 </ref>.

The protein myopodin (encoded by the gene SYNPO2[http://www.uniprot.org/uniprot/Q9UMS6]), also called genethonin-2, synaptopodin-2, synaptopodin-like and fesselin, was first described in 2001 by Weins ''et al.'', and shown to be widely expressed in striated- and smooth-muscle cells <ref> PMID:11673475 </ref> <ref> PMID:12869577 </ref>. At least six isoforms result from alternative splicing and the predicted size of the resulting proteins varies between 76 kDa and 136 kDa; these variants show differential tissue distribution. The discrepancy between calculated molecular mass and apparent mobility in SDS-PAGE is at present still unclear, but might be due to post-translational modifications <ref> PMID:20554076 </ref> <ref> PMID:18371299 </ref> <ref> PMID:11696420</ref> <ref> PMID:12917631 </ref> <ref> PMID:18588515 </ref>.

== Function==

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 ==MYOPODIN==
-The protein myopodin (encoded by the gene SYNPO2[http://www.uniprot.org/uniprot/Q9UMS6]), is also called genethonin-2, synaptopodin-2, synaptopodin-like and fesselin; it was first described in 2001 by Weins ''et al.'', and shown to be widely expressed in striated- and smooth-muscle cells <ref> PMID:11673475 </ref> <ref> PMID:12869577 </ref>. At least six isoforms result from alternative splicing and the size of the resulting proteins varies between 76 kDa and 136 kDa; these variants show differential tissue distribution. The discrepancy between calculated molecular mass and apparent mobility in SDS-PAGE is at present still unclear, but might be due to post-translational modifications <ref> PMID:20554076 </ref> <ref> PMID:18371299 </ref> <ref> PMID:11696420</ref> <ref> PMID:12917631 </ref> <ref> PMID:18588515 </ref>.
+The protein myopodin (encoded by the gene SYNPO2[http://www.uniprot.org/uniprot/Q9UMS6]), also called genethonin-2, synaptopodin-2, synaptopodin-like and fesselin, was first described in 2001 by Weins ''et al.'', and shown to be widely expressed in striated- and smooth-muscle cells <ref> PMID:11673475 </ref> <ref> PMID:12869577 </ref>. At least six isoforms result from alternative splicing and the predicted size of the resulting proteins varies between 76 kDa and 136 kDa; these variants show differential tissue distribution. The discrepancy between calculated molecular mass and apparent mobility in SDS-PAGE is at present still unclear, but might be due to post-translational modifications <ref> PMID:20554076 </ref> <ref> PMID:18371299 </ref> <ref> PMID:11696420</ref> <ref> PMID:12917631 </ref> <ref> PMID:18588515 </ref>.
 == Function==