Group:MUZIC:Myopodin: Difference between revisions

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==Pathology==

Already in 2001 Lin et al showed that ''SYNPO2'' gene exhibit frequently delations in aggresive prostata cancer <ref> PMID:11696420</ref>. Later analysis gave the evidence that Myopodin plays an important role as tumor suppressor, considering that in normal urothelium of the bladder Myopodin is localized in the cytoplasm and in the nucleus, however in mutated tissue of superficial and invasive bladder tumor is observed a reduced nuclear expression of Myopodin <ref> PMID:12917631 </ref>. Furthermore the expression of Myopodin suppressed tumor growth and metastasis <ref> PMID:15111326 </ref>. However these observations appear in contradiction with other experiments, where the expression of Myopodin at the protein level could be verify merely in muscle cells ~~<ref> PMID:15111326 </ref> <ref> PMID:15111326 </ref>~~.

Already in 2001 Lin et al showed that ''SYNPO2'' gene exhibit frequently delations in aggresive prostata cancer <ref> PMID:11696420</ref>. Later analysis gave the evidence that Myopodin plays an important role as tumor suppressor, considering that in normal urothelium of the bladder Myopodin is localized in the cytoplasm and in the nucleus, however in mutated tissue of superficial and invasive bladder tumor is observed a reduced nuclear expression of Myopodin <ref> PMID:12917631 </ref>. Furthermore the expression of Myopodin suppressed tumor growth and metastasis <ref> PMID:15111326 </ref>. However these observations appear in contradiction with other experiments from Linnemann A. Diplom Thesis 2005 and Krueger Diplom Thesis 2007, where the expression of Myopodin at the protein level could be verify merely in muscle cells.

==References==

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 ==Pathology==
-Already in 2001 Lin et al showed that ''SYNPO2'' gene exhibit frequently delations in aggresive prostata cancer <ref> PMID:11696420</ref>. Later analysis gave the evidence that Myopodin plays an important role as tumor suppressor, considering that in normal urothelium of the bladder Myopodin is localized in the cytoplasm and in the nucleus, however in mutated tissue of superficial and invasive bladder tumor is observed a reduced nuclear expression of Myopodin <ref> PMID:12917631 </ref>. Furthermore the expression of Myopodin suppressed tumor growth and metastasis <ref> PMID:15111326 </ref>. However these observations appear in contradiction with other experiments, where the expression of Myopodin at the protein level could be verify merely in muscle cells <ref> PMID:15111326 </ref> <ref> PMID:15111326 </ref>.
+Already in 2001 Lin et al showed that ''SYNPO2'' gene exhibit frequently delations in aggresive prostata cancer <ref> PMID:11696420</ref>. Later analysis gave the evidence that Myopodin plays an important role as tumor suppressor, considering that in normal urothelium of the bladder Myopodin is localized in the cytoplasm and in the nucleus, however in mutated tissue of superficial and invasive bladder tumor is observed a reduced nuclear expression of Myopodin <ref> PMID:12917631 </ref>. Furthermore the expression of Myopodin suppressed tumor growth and metastasis <ref> PMID:15111326 </ref>. However these observations appear in contradiction with other experiments from Linnemann A. Diplom Thesis 2005 and Krueger Diplom Thesis 2007, where the expression of Myopodin at the protein level could be verify merely in muscle cells.
 ==References==
 <references/>