Sandbox SouthUniversity1: Difference between revisions
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Purely based on the distance between the pheny ring of the flavone substrate and the heme iron, oxidation would be expected to take place at the 4 (para) position. However, other factors help determine the regioselectivity of the metabolism (selectivity for the different positions). One of these factors is the relative reactivity of the various positions on the substrate. | |||
Different members of the CYP450 enzymes preferentially metabolize different xenobiotics. What features of a drug do you think might cause it to be metabolized by one CYP versus another? | |||
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<insert quiz here on electrostatic and steric factors | |||
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<insert animations here contrasting the shape of the active site of CYP3A4 and e.g. CYP2E1, illustrating the size of the binding pockets and their electronic character> | |||