Group:MUZIC:Tritopodin: Difference between revisions

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==Function==

Tritopodin is expressed in vivo and in vitro in differentiated skeletal- and heart muscle cells. Tritopodin associates with polymerized actin, and is conserved amongst vertebrates, indicating an essential role in muscle function. Furthermore Tritopodin is able to translocate to the nucleus, and plays an important role in skeletal and cardiac muscle development. ~~(Linnemann 2010; Beqqali et al. 2010)~~.

Tritopodin is expressed in vivo and in vitro in differentiated skeletal- and heart muscle cells. Tritopodin associates with polymerized actin, and is conserved amongst vertebrates, indicating an essential role in muscle function. Furthermore Tritopodin is able to translocate to the nucleus, and plays an important role in skeletal and cardiac muscle development. <ref> PMID:20554076 </ref> <ref> PMID:20215401 </ref>.

==Tritopodin interactions==

Tritopodin as Synaptopodin and Myopodin localizes in the sarcomeric Z-disc, where they interact with α-actinin and Filamin C, verify by CoIPs and yeast two-hybrid assays <ref> PMID:20554076 </ref>. Adult skeletal and heart tissue shows the colocalization from mCHAP with α-actinin in the sarcomeric Z-disc and in the nucleus in embrional Cardiomyocytes ~~(Beqqali et al. 2010)~~.

Tritopodin as Synaptopodin and Myopodin localizes in the sarcomeric Z-disc, where they interact with α-actinin and Filamin C, verify by CoIPs and yeast two-hybrid assays <ref> PMID:20554076 </ref>. Adult skeletal and heart tissue shows the colocalization from mCHAP with α-actinin in the sarcomeric Z-disc and in the nucleus in embrional Cardiomyocytes <ref> PMID:20215401 </ref>.

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 ==Function==
-Tritopodin is expressed in vivo and in vitro in differentiated skeletal- and heart muscle cells. Tritopodin associates with polymerized actin, and is conserved amongst vertebrates, indicating an essential role in muscle function. Furthermore Tritopodin is able to translocate to the nucleus, and plays an important role in skeletal and cardiac muscle development. (Linnemann 2010; Beqqali et al. 2010).
+Tritopodin is expressed in vivo and in vitro in differentiated skeletal- and heart muscle cells. Tritopodin associates with polymerized actin, and is conserved amongst vertebrates, indicating an essential role in muscle function. Furthermore Tritopodin is able to translocate to the nucleus, and plays an important role in skeletal and cardiac muscle development. <ref> PMID:20554076 </ref> <ref> PMID:20215401 </ref>.
 ==Tritopodin interactions==
-Tritopodin as Synaptopodin and Myopodin localizes in the sarcomeric Z-disc, where they interact with α-actinin and Filamin C, verify by CoIPs and yeast two-hybrid assays <ref> PMID:20554076 </ref>. Adult skeletal and heart tissue shows the colocalization from mCHAP with α-actinin in the sarcomeric Z-disc and in the nucleus in embrional Cardiomyocytes (Beqqali et al. 2010).
+Tritopodin as Synaptopodin and Myopodin localizes in the sarcomeric Z-disc, where they interact with α-actinin and Filamin C, verify by CoIPs and yeast two-hybrid assays <ref> PMID:20554076 </ref>. Adult skeletal and heart tissue shows the colocalization from mCHAP with α-actinin in the sarcomeric Z-disc and in the nucleus in embrional Cardiomyocytes <ref> PMID:20215401 </ref>.