Matrix metalloproteinase: Difference between revisions
No edit summary |
No edit summary |
||
| Line 4: | Line 4: | ||
'''Matrix metalloproteinases''' (MMP) are Zinc-dependent endopeptidases. MMP degrades extracellular matrix proteins. MMPs are produced by 28 different genes and are classified according to their protein substrates. They are inhibited by proteases called tissue inhibitors of metalloproteinase (TIMP). The pro-MMP contains a pro-peptide which must be removed to render the MMP active. The images at the left and at the right correspond to one representative MMP, ''i.e.'' the crystal structure of human pro MMP1 ([[1su3]]). | '''Matrix metalloproteinases''' (MMP) are Zinc-dependent endopeptidases. MMP degrades extracellular matrix proteins. MMPs are produced by 28 different genes and are classified according to their protein substrates. They are inhibited by proteases called tissue inhibitors of metalloproteinase (TIMP). The pro-MMP contains a pro-peptide which must be removed to render the MMP active. The images at the left and at the right correspond to one representative MMP, ''i.e.'' the crystal structure of human pro MMP1 ([[1su3]]). | ||
{{TOC limit|limit=2}} | |||
{{Clear}} | {{Clear}} | ||
==MT1-MMP-TIMP-1 complex== | ==MT1-MMP-TIMP-1 complex== | ||