Matrix metalloproteinase: Difference between revisions
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Michal Harel (talk | contribs) No edit summary |
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{{STRUCTURE_1su3| PDB=1su3 | SIZE=300| SCENE= |right| CAPTION= Human pro MMP1 complex with HEPES, sulfate, Ca+2, Cl-1, Na+1, Zn+2 ions, [[1su3]] }} | {{STRUCTURE_1su3| PDB=1su3 | SIZE=300| SCENE= |right| CAPTION= Human pro MMP1 complex with HEPES, sulfate, Ca+2, Cl-1, Na+1, Zn+2 ions, [[1su3]] }} | ||
'''Matrix metalloproteinases''' (MMP) are Zinc-dependent endopeptidases. MMP degrades extracellular matrix proteins. MMPs are produced by 28 different genes and are classified according to their protein substrates. They are inhibited by proteases called tissue inhibitors of metalloproteinase (TIMP). The pro-MMP contains a pro-peptide which must be removed to render the MMP active. | '''Matrix metalloproteinases''' (MMP) are Zinc-dependent endopeptidases. MMP degrades extracellular matrix proteins. MMPs are produced by 28 different genes and are classified according to their protein substrates. They are inhibited by proteases called tissue inhibitors of metalloproteinase (TIMP). The pro-MMP contains a pro-peptide which must be removed to render the MMP active. See [[MT1-MMP-TIMP-1 complex]] for details of the complex of MMP14 and the protein inhibitor TIMP-1. | ||
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