Group:MUZIC:Enigma Family: Difference between revisions

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==Sequence annotation and domain organization==

~~'''''Enigma protein'''''~~

[[Image:Enigma_family.png|left|thumb|500px|Topological map of the PDZ- and LIM-domains in the first isoforms of the Enigma subfamily members [http://www.uniprot.org/uniprot/O75112#section_features)][http://www.uniprot.org/uniprot/Q96HC4#section_alternative][http://www.uniprot.org/uniprot/Q9NR12#section_features]]]

~~alternatively referred to as PDLIM7 (~~PDZ and LIM ~~domain protein 7) is~~ the first ~~and representative member~~ of the Enigma subfamily. ~~Initially characterized in human as ~49~~.~~85 kDa, 457 amino-acid protein with an N-terminal PDZ domain and three C-terminal LIM domains <ref>PMID~~:~~7929196<~~/~~ref> <ref>PMID:10359609<~~/~~ref>~~. ~~Five alternatively spliced isoforms are presently identified (UniProtKB ID: Q9NR12)~~[http://www.uniprot.org/uniprot/Q9NR12#section_features].

~~'''''Enigma Homologue (ENH) protein''''', also referred to as PDLIM5, is ~67 kDa, 596-amino-acid human ortholog of rat ENH~~

~~protein <ref>PMID:10429367</ref> with four alternatively spliced isoforms (UniProtKB ID: Q96HC4)[http://www.uniprot.org/uniprot/Q96HC4#section_alternative].~~

'''''ZASP''''' ('''Z'''-disk '''A'''lternatively '''S'''pliced '''P'''DZ domain protein), also referred to as LIM domain-binding protein 3 (LDB-3), is the 78 kDa, 727-amino-acid human ortholog of cypher, independently identified in heart and skeletal

'''ZASP''' ('''Z'''-disk '''A'''lternatively '''S'''pliced '''P'''DZ domain protein), also referred to as LIM domain-binding protein 3 (LDB-3), is the 78 kDa, 727-amino-acid human ortholog of cypher, independently identified in heart and skeletal

muscle<ref>PMID:10427098</ref>. Five alternatively spliced isoforms of ZASP have been identified (UniProtKB: O75112)[http://www.uniprot.org/uniprot/O75112#section_features)]. Apart from the PDZ domain, ZASP possess an internal motif (ZASP-like motif) which confers the ability to interact with the spectrin repeats of α-actinin-2 <ref>doi:10.1016/j.yexcr.2005.12.036</ref>.

'''~~Topological map~~''' of ~~the~~ PDZ- and LIM~~-domains of~~ the ~~three~~ member ~~proteins (human)~~ of Enigma subfamily is as ~~illustrated below~~:

'''Enigma Homologue (ENH)''' protein, also referred to as PDLIM5, is ~67 kDa, 596-amino-acid human ortholog of rat ENH

[[~~Image~~:~~Enigma_family~~.~~png]~~]

protein <ref>PMID:10429367</ref> with four alternatively spliced isoforms (UniProtKB ID: Q96HC4)[http://www.uniprot.org/uniprot/Q96HC4#section_alternative].

'''Enigma''' protein

alternatively referred to as PDLIM7 (PDZ and LIM domain protein 7) is the first and representative member of the Enigma subfamily. Initially characterized in human as ~49.85 kDa, 457 amino-acid protein with an N-terminal PDZ domain and three C-terminal LIM domains <ref>PMID:7929196</ref> <ref>PMID:10359609</ref>. Five alternatively spliced isoforms are presently identified (UniProtKB ID: Q9NR12)[http://www.uniprot.org/uniprot/Q9NR12#section_features].

==Structure==

@@ Line 5: / Line 5: @@
 ==Sequence annotation and domain organization==
-'''''Enigma protein'''''
+[[Image:Enigma_family.png|left|thumb|500px|Topological map of the PDZ- and LIM-domains in the first isoforms of the Enigma subfamily members [http://www.uniprot.org/uniprot/O75112#section_features)][http://www.uniprot.org/uniprot/Q96HC4#section_alternative][http://www.uniprot.org/uniprot/Q9NR12#section_features]]]
-alternatively referred to as PDLIM7 (PDZ and LIM domain protein 7) is the first and representative member of the Enigma subfamily. Initially characterized in human as ~49.85 kDa, 457 amino-acid protein with an N-terminal PDZ domain and three C-terminal LIM domains <ref>PMID:7929196</ref> <ref>PMID:10359609</ref>. Five alternatively spliced isoforms are presently identified (UniProtKB ID: Q9NR12)[http://www.uniprot.org/uniprot/Q9NR12#section_features].
-'''''Enigma Homologue (ENH) protein''''', also referred to as PDLIM5, is ~67 kDa, 596-amino-acid human ortholog of rat ENH
-protein <ref>PMID:10429367</ref> with four alternatively spliced isoforms (UniProtKB ID: Q96HC4)[http://www.uniprot.org/uniprot/Q96HC4#section_alternative].
-'''''ZASP''''' ('''Z'''-disk '''A'''lternatively '''S'''pliced '''P'''DZ domain protein), also referred to as LIM domain-binding protein 3 (LDB-3), is the 78 kDa, 727-amino-acid human ortholog of cypher, independently identified in heart and skeletal
+'''ZASP''' ('''Z'''-disk '''A'''lternatively '''S'''pliced '''P'''DZ domain protein), also referred to as LIM domain-binding protein 3 (LDB-3), is the 78 kDa, 727-amino-acid human ortholog of cypher, independently identified in heart and skeletal
 muscle<ref>PMID:10427098</ref>. Five alternatively spliced isoforms of ZASP have been identified (UniProtKB: O75112)[http://www.uniprot.org/uniprot/O75112#section_features)]. Apart from the PDZ domain, ZASP possess an internal motif (ZASP-like motif) which confers the ability to interact with the spectrin repeats of α-actinin-2 <ref>doi:10.1016/j.yexcr.2005.12.036</ref>.
-'''Topological map''' of the PDZ- and LIM-domains of the three member proteins (human) of Enigma subfamily is as illustrated below:
+'''Enigma Homologue (ENH)''' protein, also referred to as PDLIM5, is ~67 kDa, 596-amino-acid human ortholog of rat ENH
-               [[Image:Enigma_family.png]]
+protein <ref>PMID:10429367</ref> with four alternatively spliced isoforms (UniProtKB ID: Q96HC4)[http://www.uniprot.org/uniprot/Q96HC4#section_alternative].
+'''Enigma''' protein
+alternatively referred to as PDLIM7 (PDZ and LIM domain protein 7) is the first and representative member of the Enigma subfamily. Initially characterized in human as ~49.85 kDa, 457 amino-acid protein with an N-terminal PDZ domain and three C-terminal LIM domains <ref>PMID:7929196</ref> <ref>PMID:10359609</ref>. Five alternatively spliced isoforms are presently identified (UniProtKB ID: Q9NR12)[http://www.uniprot.org/uniprot/Q9NR12#section_features].
 ==Structure==