Group:MUZIC:Enigma Family: Difference between revisions

Line 6:

'''''Enigma protein'''''

alternatively referred to as PDLIM7 (PDZ and LIM domain protein 7) is the first and representative member of the Enigma subfamily. Initially characterized in human as ~49.85 kDa, 457 amino-acid protein with an N-terminal PDZ domain and three C-terminal LIM domains <ref>PMID:7929196</ref>, <ref>PMID:10359609</ref>. Five alternatively spliced isoforms are presently identified [http://www.uniprot.org/uniprot/Q9NR12#section_features]

alternatively referred to as PDLIM7 (PDZ and LIM domain protein 7) is the first and representative member of the Enigma subfamily. Initially characterized in human as ~49.85 kDa, 457 amino-acid protein with an N-terminal PDZ domain and three C-terminal LIM domains <ref>PMID:7929196</ref> <ref>PMID:10359609</ref>. Five alternatively spliced isoforms are presently identified (UniProtKB ID: Q9NR12)[http://www.uniprot.org/uniprot/Q9NR12#section_features].

'''''Enigma Homologue (ENH) protein''''', also referred to as PDLIM5, is ~67 kDa, 596-amino-acid human ortholog of rat ENH

protein <ref>PMID:10429367</ref> with four alternatively spliced isoforms (UniProtKB: Q96HC4)[http://www.uniprot.org/uniprot/Q96HC4#section_alternative].

protein <ref>PMID:10429367</ref> with four alternatively spliced isoforms (UniProtKB ID: Q96HC4)[http://www.uniprot.org/uniprot/Q96HC4#section_alternative].

'''''ZASP'''''('''Z'''-disk '''a'''lternatively '''s'''pliced '''P'''DZ domain protein), also referred to as LIM domain-binding protein 3 (LDB-3), is the 78 kDa, 727-amino-acid human ortholog of cypher, independently identified in heart and skeletal

'''''ZASP''''' ('''Z'''-disk '''A'''lternatively '''S'''pliced '''P'''DZ domain protein), also referred to as LIM domain-binding protein 3 (LDB-3), is the 78 kDa, 727-amino-acid human ortholog of cypher, independently identified in heart and skeletal

muscle<ref>PMID:10427098</ref>. Five alternatively spliced isoforms of ZASP have been identified (UniProtKB: O75112)[http://www.uniprot.org/uniprot/O75112#section_features)]. ZASP ~~contains a~~ motif (ZASP-like motif) which ~~has been identified~~ to interact with the spectrin repeats of α-actinin <ref>doi:10.1016/j.yexcr.2005.12.036</ref>

muscle<ref>PMID:10427098</ref>. Five alternatively spliced isoforms of ZASP have been identified (UniProtKB: O75112)[http://www.uniprot.org/uniprot/O75112#section_features)]. Apart from the PDZ domain, ZASP possess an internal motif (ZASP-like motif) which confers the ability to interact with the spectrin repeats of α-actinin-2 <ref>doi:10.1016/j.yexcr.2005.12.036</ref>.

'''Topological map''' of the PDZ- and LIM-domains of the three member proteins (human) of Enigma subfamily is as illustrated below:

@@ Line 6: / Line 6: @@
 '''''Enigma protein'''''
-alternatively referred to as PDLIM7 (PDZ and LIM domain protein 7) is the first and representative member of the Enigma subfamily. Initially characterized in human as ~49.85 kDa, 457 amino-acid protein with an N-terminal PDZ domain and three C-terminal LIM domains <ref>PMID:7929196</ref>, <ref>PMID:10359609</ref>. Five alternatively spliced isoforms are presently identified [http://www.uniprot.org/uniprot/Q9NR12#section_features]
+alternatively referred to as PDLIM7 (PDZ and LIM domain protein 7) is the first and representative member of the Enigma subfamily. Initially characterized in human as ~49.85 kDa, 457 amino-acid protein with an N-terminal PDZ domain and three C-terminal LIM domains <ref>PMID:7929196</ref> <ref>PMID:10359609</ref>. Five alternatively spliced isoforms are presently identified (UniProtKB ID: Q9NR12)[http://www.uniprot.org/uniprot/Q9NR12#section_features].
 '''''Enigma Homologue (ENH) protein''''', also referred to as PDLIM5, is ~67 kDa, 596-amino-acid human ortholog of rat ENH
-protein <ref>PMID:10429367</ref> with four alternatively spliced isoforms (UniProtKB: Q96HC4)[http://www.uniprot.org/uniprot/Q96HC4#section_alternative].
+protein <ref>PMID:10429367</ref> with four alternatively spliced isoforms (UniProtKB ID: Q96HC4)[http://www.uniprot.org/uniprot/Q96HC4#section_alternative].
-'''''ZASP'''''('''Z'''-disk '''a'''lternatively '''s'''pliced '''P'''DZ domain protein), also referred to as LIM domain-binding protein 3 (LDB-3), is the 78 kDa, 727-amino-acid human ortholog of cypher, independently identified in heart and skeletal
+'''''ZASP''''' ('''Z'''-disk '''A'''lternatively '''S'''pliced '''P'''DZ domain protein), also referred to as LIM domain-binding protein 3 (LDB-3), is the 78 kDa, 727-amino-acid human ortholog of cypher, independently identified in heart and skeletal
-muscle<ref>PMID:10427098</ref>. Five alternatively spliced isoforms of ZASP have been identified (UniProtKB: O75112)[http://www.uniprot.org/uniprot/O75112#section_features)]. ZASP contains a motif (ZASP-like motif) which has been identified to interact with the spectrin repeats of α-actinin <ref>doi:10.1016/j.yexcr.2005.12.036</ref>
+muscle<ref>PMID:10427098</ref>. Five alternatively spliced isoforms of ZASP have been identified (UniProtKB: O75112)[http://www.uniprot.org/uniprot/O75112#section_features)]. Apart from the PDZ domain, ZASP possess an internal motif (ZASP-like motif) which confers the ability to interact with the spectrin repeats of α-actinin-2 <ref>doi:10.1016/j.yexcr.2005.12.036</ref>.
 '''Topological map''' of the PDZ- and LIM-domains of the three member proteins (human) of Enigma subfamily is as illustrated below: