Inositol 1,4,5-Trisphosphate Receptor: Difference between revisions
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The InsP<sub>3</sub>R protein can autophosphorylate itself and is a substrate for multiple protein kinases.<ref name="functionref"/> These kinases include cyclic AMP-dependent protein kinase (PKA), cyclic GMP-dependent protein kinase (PKG) and others.<ref name="functionref"/> The protein kinases are thought to interact with the InsP<sub>3</sub> receptor by controlling the sensitivity to Ca<sup>2+</sup> in different tissues as well as affecting the sensitivity of InsP<sub>3</sub> itself to Ca<sup>2+</sup>.<ref name="functionref"/> | The InsP<sub>3</sub>R protein can autophosphorylate itself and is a substrate for multiple protein kinases.<ref name="functionref"/> These kinases include cyclic AMP-dependent protein kinase (PKA), cyclic GMP-dependent protein kinase (PKG) and others.<ref name="functionref"/> The protein kinases are thought to interact with the InsP<sub>3</sub> receptor by controlling the sensitivity to Ca<sup>2+</sup> in different tissues as well as affecting the sensitivity of InsP<sub>3</sub> itself to Ca<sup>2+</sup>.<ref name="functionref"/> | ||
===3D structures of inositol 1,4,5-trisphosphate receptor=== | |||
[[3jrr]] – mInsP3R III ligand-binding suppressor domain – mouse<br /> | |||
[[1xzz]] - mInsP3R I ligand-binding suppressor domain<br /> | |||
[[1n4k]] - mInsP3R I receptor-binding core + ligand | |||
==References== | ==References== | ||
<references /> | <references /> | ||