Group:MUZIC:Tritopodin: Difference between revisions

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==TRITOPODIN==

Tritopodin is the third member and ~~less researched~~ of the podin family proteins and is codified by the gene ''SYNPO2L''. Tritopodin also known under the names synaptopodin 2-like, Myopodin-like and CHAP (cytoskeletal heart-enriched actin-associated protein), is found in heart ~~(Claeys et al. 2009) <ref> PMID:19151983 </ref>~~ and skeletal muscle tissue (~~Beqqali~~ et al. ~~2010~~) <ref> PMID:~~20215401~~ </ref>. Tritopodin share with Myopodin 33% of homology in the Aminoacid sequence, which makes believe similar functions for both proteins. Tritopodin gene it is form by 5 exons and 2 isoforms are postulated: mCHAPa from exon 1,2,3 and 5, as well as mCHAPb that result from a start-codon in exon 4, from which derives two proteins variants of 140kDa (mCHAPa) and 110kDa (mCHAPb).

Tritopodin is the third member (besides myopodin and synaptopodin) of the podin family proteins and is codified by the gene ''SYNPO2L''. Tritopodin has been revealed by database searches, and since it is the third member of a family of proteins with extended sequence similarity, was named ‘‘tritopodin’’. Tritopodin is also known under the names synaptopodin 2-like, Myopodin-like and CHAP (cytoskeletal heart-enriched actin-associated protein), is found in heart and skeletal muscle tissue (Claeys et al. 2009) <ref> PMID:19151983 </ref> . Tritopodin share with Myopodin 33% of homology in the Aminoacid sequence, which makes believe similar functions for both proteins. Tritopodin gene it is form by 5 exons and 2 isoforms are postulated: mCHAPa from exon 1,2,3 and 5, as well as mCHAPb that result from a start-codon in exon 4, from which derives two proteins variants of 140kDa (mCHAPa) and 110kDa (mCHAPb)(Beqqali et al. 2010) <ref> PMID:20215401 </ref>.

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	==TRITOPODIN==		==TRITOPODIN==
	Tritopodin is the third member and ~~less researched~~ of the podin family proteins and is codified by the gene ''SYNPO2L''. Tritopodin also known under the names synaptopodin 2-like, Myopodin-like and CHAP (cytoskeletal heart-enriched actin-associated protein), is found in heart ~~(Claeys et al. 2009) <ref> PMID:19151983 </ref>~~ and skeletal muscle tissue (~~Beqqali~~ et al. ~~2010~~) <ref> PMID:~~20215401~~ </ref>. Tritopodin share with Myopodin 33% of homology in the Aminoacid sequence, which makes believe similar functions for both proteins. Tritopodin gene it is form by 5 exons and 2 isoforms are postulated: mCHAPa from exon 1,2,3 and 5, as well as mCHAPb that result from a start-codon in exon 4, from which derives two proteins variants of 140kDa (mCHAPa) and 110kDa (mCHAPb).		Tritopodin is the third member (besides myopodin and synaptopodin) of the podin family proteins and is codified by the gene ''SYNPO2L''. Tritopodin has been revealed by database searches, and since it is the third member of a family of proteins with extended sequence similarity, was named ‘‘tritopodin’’. Tritopodin is also known under the names synaptopodin 2-like, Myopodin-like and CHAP (cytoskeletal heart-enriched actin-associated protein), is found in heart and skeletal muscle tissue (Claeys et al. 2009) <ref> PMID:19151983 </ref> . Tritopodin share with Myopodin 33% of homology in the Aminoacid sequence, which makes believe similar functions for both proteins. Tritopodin gene it is form by 5 exons and 2 isoforms are postulated: mCHAPa from exon 1,2,3 and 5, as well as mCHAPb that result from a start-codon in exon 4, from which derives two proteins variants of 140kDa (mCHAPa) and 110kDa (mCHAPb)(Beqqali et al. 2010) <ref> PMID:20215401 </ref>.