Group:MUZIC:Tritopodin: Difference between revisions

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== TRITOPODIN==

Tritopodin is the third member and less researched of the podin family proteins. Tritopodin also known ~~ander~~ the names synaptopodin 2-like and CHAP is found in heart (Claeys et al. 2009) <ref> PMID:19151983 </ref> and skeletal muscle tissue (Beqqali et al. 2010) <ref> PMID:20215401 </ref>.

Tritopodin is the third member and less researched of the podin family proteins and is codified by the gene ''SYNPO2L''. Tritopodin also known under the names synaptopodin 2-like, Myopodin-like and CHAP (cytoskeletal heart-enriched actin-associated protein), is found in heart (Claeys et al. 2009) <ref> PMID:19151983 </ref> and skeletal muscle tissue (Beqqali et al. 2010) <ref> PMID:20215401 </ref>. Tritopodin share with Myopodin 33% of homology in the Aminoacid sequence, which makes believe similar functions for both proteins. Tritopodin gene it is form by 5 exons and 2 isoforms are postulated: mCHAPa from exon 1,2,3 and 5, as well as mCHAPb that result from a start-codon in exon 4 and the two derives proteins are of 140kDa (mCHAPa) und 110kDa (mCHAPb).

==Function==

mCHAP is expressed in vivo and in vitro in di�fferentiated skeletal- and heart muscle cells.

==Tritopodin interactions==

Tritopodin as Synaptopodin and Myopodin localizes in the sarcomeric Z-disc, where they interact with α-actinin and Filamin C, verify by CoIPs and yeast two-hybrid assays (Glaesker, 2009; Linnemann et al. 2010; Rieck, 2010)) Adult skeletal and heart tissue shows the colocalization from mCHAP with α-actinin in the sarcomeric Z-disc and in the nucleus in embrional Cardiomyocytes (Beqqali et al. 2010).

[[Image:Tritopodin.jpg|500x]]

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 == TRITOPODIN==
-Tritopodin is the third member and less researched of the podin family proteins. Tritopodin also known ander the names synaptopodin 2-like and CHAP is found in heart (Claeys et al. 2009) <ref> PMID:19151983 </ref> and skeletal muscle tissue (Beqqali et al. 2010) <ref> PMID:20215401 </ref>.
+Tritopodin is the third member and less researched of the podin family proteins and is codified by the gene ''SYNPO2L''. Tritopodin also known under the names synaptopodin 2-like, Myopodin-like and CHAP (cytoskeletal heart-enriched actin-associated protein), is found in heart (Claeys et al. 2009) <ref> PMID:19151983 </ref> and skeletal muscle tissue (Beqqali et al. 2010) <ref> PMID:20215401 </ref>. Tritopodin share with Myopodin 33% of homology in the Aminoacid sequence, which makes believe similar functions for both proteins. Tritopodin gene it is form by 5 exons and 2 isoforms are postulated: mCHAPa from exon 1,2,3 and 5, as well as mCHAPb that result from a start-codon in exon 4 and the two derives proteins are of 140kDa (mCHAPa) und 110kDa (mCHAPb).
 ==Function==
+mCHAP is expressed in vivo and in vitro in di�fferentiated skeletal- and heart muscle cells.
+==Tritopodin interactions==
+Tritopodin as Synaptopodin and Myopodin localizes in the sarcomeric Z-disc, where they interact with α-actinin and Filamin C, verify by CoIPs and yeast two-hybrid assays (Glaesker, 2009; Linnemann et al. 2010; Rieck, 2010)) Adult skeletal and heart tissue shows the colocalization from mCHAP with α-actinin in the sarcomeric Z-disc and in the nucleus in embrional Cardiomyocytes (Beqqali et al. 2010).
 [[Image:Tritopodin.jpg|500x]]