1a2a: Difference between revisions
New page: left|200px<br /> <applet load="1a2a" size="450" color="white" frame="true" align="right" spinBox="true" caption="1a2a, resolution 2.80Å" /> '''AGKISTROTOXIN, A PH... |
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==About this Structure== | ==About this Structure== | ||
1A2A is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Gloydius_halys Gloydius halys]] with CL as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1A2A OCA]]. | 1A2A is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Gloydius_halys Gloydius halys]] with CL as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4]]. Structure known Active Site: NIC. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1A2A OCA]]. | ||
==Reference== | ==Reference== | ||
Crystal structure of agkistrodotoxin, a phospholipase A2-type presynaptic neurotoxin from agkistrodon halys pallas., Tang L, Zhou YC, Lin ZJ, J Mol Biol. 1998 Sep 11;282(1):1-11. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9733637 9733637] | Crystal structure of agkistrodotoxin, a phospholipase A2-type presynaptic neurotoxin from agkistrodon halys pallas., Tang L, Zhou YC, Lin ZJ, J Mol Biol. 1998 Sep 11;282(1):1-11. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9733637 9733637] | ||
[[Category: Gloydius halys]] | [[Category: Gloydius halys]] | ||
[[Category: Phospholipase A(2)]] | |||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Lin, Z.]] | [[Category: Lin, Z.]] | ||
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[[Category: presynaptic neurotoxin]] | [[Category: presynaptic neurotoxin]] | ||
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Revision as of 13:03, 30 October 2007
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AGKISTROTOXIN, A PHOSPHOLIPASE A2-TYPE PRESYNAPTIC NEUROTOXIN FROM AGKISTRODON HALYS PALLAS
OverviewOverview
The crystal structure of agkistrodotoxin containing eight copies of, molecules in the asymmetric unit has been determined at 2.8 A resolution, to a crystallographic R factor of 0.207 by the molecular replacement, technique. Two spatially adjacent regions of agkistrodotoxin molecule, turn 55-61 and stretch 85-91, are remarkably different from those of, non-neurotoxic isoforms in conformation and electrostatic characteristics., These regions are likely to be involved in the recognition of, agkistrodotoxin towards the specific receptor at the presynaptic membrane., The structural comparison of the interfacial recognition site with, non-neurotoxic isoforms reveals a decreased hydrophobicity and lack of, residues with bulky hydrophobic side-chains (i.e. Trp) to serve as, membrane anchors. This ... [(full description)]
About this StructureAbout this Structure
1A2A is a [Single protein] structure of sequence from [Gloydius halys] with CL as [ligand]. Active as [Phospholipase A(2)], with EC number [3.1.1.4]. Structure known Active Site: NIC. Full crystallographic information is available from [OCA].
ReferenceReference
Crystal structure of agkistrodotoxin, a phospholipase A2-type presynaptic neurotoxin from agkistrodon halys pallas., Tang L, Zhou YC, Lin ZJ, J Mol Biol. 1998 Sep 11;282(1):1-11. PMID:9733637
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