Neurexin: Difference between revisions
Michal Harel (talk | contribs) No edit summary |
No edit summary |
||
| Line 2: | Line 2: | ||
{{STRUCTURE_3bod| PDB=3bod | SIZE=300| SCENE=Neurexin/Cv/1 |right|CAPTION=Mouse β-neurexin 1 [[3bod]] }} | {{STRUCTURE_3bod| PDB=3bod | SIZE=300| SCENE=Neurexin/Cv/1 |right|CAPTION=Mouse β-neurexin 1 [[3bod]] }} | ||
[[Neurexin|Neurexins]] (NRXN) are a family of presynaptic proteins which bind to the postsynaptic [[Neuroligin]] (NLGN) to form a complex which attaches neurons. The NRXN family contains 4 members which are numbered 1 to 4. The α | [[Neurexin|Neurexins]] (NRXN) are a family of presynaptic proteins which bind to the postsynaptic [[Neuroligin]] (NLGN) to form a complex which attaches neurons. The NRXN family contains 4 members which are numbered 1 to 4. The NRXN-α contains 6 homologous LNS domains while the NRXN-β contains only LNS6. The images at the left and at the right correspond to one representative NRXN, ''i.e.'' the crystal structure of mouse β-neurexin 1 ([[3bod]]). | ||
For Structural Analysis of Neurexin, See: [[Neuroligin-Neurexin Interaction]] | For Structural Analysis of Neurexin, See: [[Neuroligin-Neurexin Interaction]] | ||
| Line 42: | Line 42: | ||
[[3b3q]] - hNRXN-1 LNS domain+mNLGN-1 cholinesterase domain<br /> | [[3b3q]] - hNRXN-1 LNS domain+mNLGN-1 cholinesterase domain<br /> | ||
[[3biw]] - rβ-NRXN-1 +rNLGN-1 cholinesterase domain<br /> | [[3biw]] - rβ-NRXN-1 +rNLGN-1 cholinesterase domain<br /> | ||
===NRXN=== | |||
[[3mw2]] – mNRXN-1α LNS domain+splice insert 4 – mouse<br /> | |||
[[3bod]], [[3bop]] - mNRXN-1α LNS domain<br /> | |||
[[3mw3]], [[2r1b]] - rNRXN-1α LNS domain+splice insert 4 – rat<br /> | |||
[[2r16]] - rNRXN-1α LNS domain+Ca<br /> | |||
[[1c4r]] - rNRXN-1α LNS domain<br /> | |||
[[3mw4]] - mNRXN-1α LNS domain<br /> | |||
[[2h0b]] - bNRXN-1α LNS2 domain – bovine<br /> | |||
[[3asi]] - bNRXN-1α LNS25-EGF3-LNS6 domains<br /> | |||
===NRXN+NLGN=== | |||
[[2xb6]], [[2wqz]] – rNRXN-1α LNS domain +hNLGN-4 cholinesterase domain<br /> | |||
[[3b3q]] - hNRXN-1α LNS domain+mNLGN-4 cholinesterase domain<br /> | |||
[[3biw]] - rNRXN-1α LNS domain+rNLGN-1 cholinesterase domain<br /> | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 14:09, 16 June 2011
Neurexins (NRXN) are a family of presynaptic proteins which bind to the postsynaptic Neuroligin (NLGN) to form a complex which attaches neurons. The NRXN family contains 4 members which are numbered 1 to 4. The NRXN-α contains 6 homologous LNS domains while the NRXN-β contains only LNS6. The images at the left and at the right correspond to one representative NRXN, i.e. the crystal structure of mouse β-neurexin 1 (3bod).
For Structural Analysis of Neurexin, See: Neuroligin-Neurexin Interaction
3D Structures of Neurexin3D Structures of Neurexin
Update June 2011
α-NRXNα-NRXN
2h0b - bα-NRXN-1 LNS2 – bovine
2r16 - bα-NRXN-1 LNS 4
β-NRXNβ-NRXN
3mw2 – mβ-NRXN-1 +splice insert 4 – mouse
3bod - mβ-NRXN-1
3bop - mβ-NRXN-2d4
3mw3, 2r1b - rβ-NRXN-2 +splice insert 4 – rat
2r1b - rβ-NRXN-1 +splice insert 4
2r1d - rβ-NRXN-1 +Ca
1c4r - rβ-NRXN-1
3mw4 - mβ-NRXN-3
NRXN+NLGNNRXN+NLGN
2xb6, 2wqz – rβ-NRXN-1 +hNLGN-4 cholinesterase domain
3b3q - hNRXN-1 LNS domain+mNLGN-1 cholinesterase domain
3biw - rβ-NRXN-1 +rNLGN-1 cholinesterase domain
NRXNNRXN
3mw2 – mNRXN-1α LNS domain+splice insert 4 – mouse
3bod, 3bop - mNRXN-1α LNS domain
3mw3, 2r1b - rNRXN-1α LNS domain+splice insert 4 – rat
2r16 - rNRXN-1α LNS domain+Ca
1c4r - rNRXN-1α LNS domain
3mw4 - mNRXN-1α LNS domain
2h0b - bNRXN-1α LNS2 domain – bovine
3asi - bNRXN-1α LNS25-EGF3-LNS6 domains
NRXN+NLGNNRXN+NLGN
2xb6, 2wqz – rNRXN-1α LNS domain +hNLGN-4 cholinesterase domain
3b3q - hNRXN-1α LNS domain+mNLGN-4 cholinesterase domain
3biw - rNRXN-1α LNS domain+rNLGN-1 cholinesterase domain