1w4a: Difference between revisions
New page: left|200px<br /> <applet load="1w4a" size="450" color="white" frame="true" align="right" spinBox="true" caption="1w4a, resolution 2.4Å" /> '''P4 PROTEIN FROM PHI1... |
No edit summary |
||
| Line 8: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
1W4A is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Pseudomonas_phage_phi12 Pseudomonas phage phi12]] with MN and APC as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1W4A OCA]]. | 1W4A is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Pseudomonas_phage_phi12 Pseudomonas phage phi12]] with MN and APC as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1W4A OCA]]. | ||
==Reference== | ==Reference== | ||
| Line 29: | Line 29: | ||
[[Category: virus dsrna]] | [[Category: virus dsrna]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:07:24 2007'' | ||
Revision as of 13:02, 30 October 2007
|
P4 PROTEIN FROM PHI12 IN COMPLEX WITH AMPCPP AND MN
OverviewOverview
Many viruses package their genome into preformed capsids using packaging, motors powered by the hydrolysis of ATP. The hexameric ATPase P4 of dsRNA, bacteriophage phi12, located at the vertices of the icosahedral capsid, is, such a packaging motor. We have captured crystallographic structures of P4, for all the key points along the catalytic pathway, including apo, substrate analog bound, and product bound. Substrate and product binding, have been observed as both binary complexes and ternary complexes with, divalent cations. These structures reveal large movements of the putative, RNA binding loop, which are coupled with nucleotide binding and, hydrolysis, indicating how ATP hydrolysis drives RNA translocation through, cooperative conformational changes. Two distinct conformations of ... [(full description)]
About this StructureAbout this Structure
1W4A is a [Single protein] structure of sequence from [Pseudomonas phage phi12] with MN and APC as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
ReferenceReference
Atomic snapshots of an RNA packaging motor reveal conformational changes linking ATP hydrolysis to RNA translocation., Mancini EJ, Kainov DE, Grimes JM, Tuma R, Bamford DH, Stuart DI, Cell. 2004 Sep 17;118(6):743-55. PMID:15369673
Page seeded by OCA on Tue Oct 30 12:07:24 2007