Factor Xa: Difference between revisions
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==Structure== | ==Structure== | ||
<Structure load='2PR3' size='300' frame='true' align='right' caption='Factor Xa: 2PR3' scene='Insert optional scene name here' /> | <Structure load='2PR3' size='300' frame='true' align='right' caption='Factor Xa: heavy chain catalytic domain + light chain EGF-like domain complex with inhibitor [[2PR3]]' scene='Insert optional scene name here' /> | ||
Factor Xa is a member of the chymotrypsin-like clan within the serine protease family. Other clans within the mammalian family are the subtilisin-like and α/β-hydrolase fold serine proteases. <scene name='Factor_Xa/Transparent_-_no_inhib_evoluti/1'>Structural homology </scene>is seen in the mammalian serine protease family, and is particularly conserved in the active site geometry of the catalytic triad. The mammalian serine protease family is an example of divergent evolution from a common ancestor. <ref name="evolution">Department of Chemistry, University of Maine, Orono, ME. http://chemistry.umeche.maine.edu/CHY252/Peptidase3.html</ref>. | Factor Xa is a member of the chymotrypsin-like clan within the serine protease family. Other clans within the mammalian family are the subtilisin-like and α/β-hydrolase fold serine proteases. <scene name='Factor_Xa/Transparent_-_no_inhib_evoluti/1'>Structural homology </scene>is seen in the mammalian serine protease family, and is particularly conserved in the active site geometry of the catalytic triad. The mammalian serine protease family is an example of divergent evolution from a common ancestor. <ref name="evolution">Department of Chemistry, University of Maine, Orono, ME. http://chemistry.umeche.maine.edu/CHY252/Peptidase3.html</ref>. | ||