Factor IX: Difference between revisions

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Nadia Dorochko, Alexander Berchansky, David Canner, Michal Harel

Revision as of 13:21, 1 June 2011 view source Michal Harel (talk \| contribs) 31,761 edits No edit summary ← Older edit		Revision as of 13:32, 1 June 2011 view source Michal Harel (talk \| contribs) 31,761 edits No edit summary Newer edit →
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	{{STRUCTURE_1pfx\| PDB=1pfx \| SCENE= }}		{{STRUCTURE_1pfx\| PDB=1pfx \| SIZE=300\| SCENE= \|right\| CAPTION=pig factor IX complex with tripeptide, [[1pfx]] }}

	<span style="color:Brown">'''<scene name='Factor_IX/Ixstructure/4'>Factor IX</scene>'''</span> (plasma thromboplastin component, Christmas factor, or hemophilia B factor) is a 57-kDa vitamin K-dependent procoagulant glycoprotein. It is synthesized by the liver hepatocyte as a [[pre-prozymogen]] that requires extensive posttranslational modification<ref>PMID:2169923</ref>. The [[pre-prozymogen]] contains a pre-peptide (hydrophobic signal peptide) at its amino terminal that transports the growing polypeptide into the lumen of the Endoplasmic Reticulum. Once inside the ER, this signal peptide is cleaved by a signal peptidase.		<span style="color:Brown">'''<scene name='Factor_IX/Ixstructure/4'>Factor IX</scene>'''</span> (plasma thromboplastin component, Christmas factor, or hemophilia B factor) is a 57-kDa vitamin K-dependent procoagulant glycoprotein. It is synthesized by the liver hepatocyte as a [[pre-prozymogen]] that requires extensive posttranslational modification<ref>PMID:2169923</ref>. The [[pre-prozymogen]] contains a pre-peptide (hydrophobic signal peptide) at its amino terminal that transports the growing polypeptide into the lumen of the Endoplasmic Reticulum. Once inside the ER, this signal peptide is cleaved by a signal peptidase.