Sandbox SouthUniversity1: Difference between revisions
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This tutorial covers the basic structure and function of the '''Cytochrome P450''' (CYP) enzymes, the most important group of drug metabolizing enzymes. The example used here for illustration purposes is the second protein discovered in the CYP 1 family, in subfamily A (generally referred to as '''CYP1A2'''). This protein is shown in an interactive window below | This tutorial covers the basic structure and function of the '''Cytochrome P450''' (CYP) enzymes, the most important group of drug metabolizing enzymes. The example used here for illustration purposes is the second protein discovered in the CYP 1 family, in subfamily A (generally referred to as '''CYP1A2'''). This protein is shown in an interactive window below. | ||
'''Turn off''' (toggle) '''spinning''' of the protein by clicking on the button below the structure. The quality of the molecule rendering can also be increased by clicking the '''"toggle quality"''' button, although this may decrease the smoothness when the molecule is rotating. | |||
Now '''rotate''' the molecule by clicking and dragging in the window with your cursor. '''Resize''' the molecule by holding down the shift key and dragging up and down. Rotate and resize the molecule until you can clearly see that there are 2 molecules shown in a "space-filling" representation in the middle of the protein. These are a heme molecule, which is absolutely vital for the enzyme's function, and a second molecule (alpha-naphthoflavone) which represents a drug that is about to be metabolized. | |||
<quiz display=simple> | <quiz display=simple> | ||
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<scene name='Sandbox_SouthUniversity1/Act_residues_cpk/1'>Residues in active site colored by atom type</scene> | <scene name='Sandbox_SouthUniversity1/Act_residues_cpk/1'>Residues in active site colored by atom type</scene> | ||
'''References''' | |||
The structure of CYP1A2 shown above is found in the Research Collaboration of Structural Bioinformatics Protein Database as entry [[2HI4]]. | |||