Bacterial Replication Termination: Difference between revisions

<StructureSection load='1f4k' size='500' side='right' caption='The Replication Terminator Protein (RTP) complexed to it's ''ter'' site' scene=''>Replication Termination Protein (RTP), found in ''Bacillus subtilis'', is a member of the ‘winged helix’ protein family, and terminates bacterial DNA replication by arresting the replication forks through interactions with DNA in a sequence specific manner [9]. RTP blocks the replication fork through contrahelicase activity; the ability to specifically inhibit the helicase replication machinery and has an additional role in arresting transcription [1][2]. In ''B. subtilis'' the bipartite ''ter'' sequence is overlapping, and each inverted repeat contains core (IRIB) and an auxillary (IRIA) sites. RTP binds to these sequences, resulting in the impediment the replication fork helicase.