Chitinase: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
[[Image: | [[Image:1edq.png|left|200px|thumb|Crystal Structure of Chitinase I from ''Serratia marcescens'', [[1edq]]]] | ||
{{ | {{STRUCTURE_1edq| PDB=1edq | SIZE=300| SCENE=Chitinases/Cv/2 |right|CAPTION=Chitinase I from ''Serratia marcescens'', [[1edq]] }} | ||
[[Chitinases]] cleave the beta-1-4-glycosidic bond between the N-acetyl-D-glucosamine units of which chitin is comprised. Chitinases are present in plants, bacteria and fungi. The first chitinase structures were solved in 1994, from a bacterium ([[1ctn]]) and a plant ([[2hvm]]). A mechanism for chitin cleavage was proposed based on several structures and was later confirmed. The images at the left and at the right correspond to one representative Chitinase, ''i.e.'' the crystal structure of Chitinase I from ''Serratia marcescens'' | [[Chitinases]] cleave the beta-1-4-glycosidic bond between the N-acetyl-D-glucosamine units of which chitin is comprised. Chitinases are present in plants, bacteria and fungi. The first chitinase structures were solved in 1994, from a bacterium ([[1ctn]]) and a plant ([[2hvm]]). A mechanism for chitin cleavage was proposed based on several structures and was later confirmed. The images at the left and at the right correspond to one representative Chitinase, ''i.e.'' the crystal structure of Chitinase I from ''Serratia marcescens'' ([[1edq]]). | ||
{{TOC limit|limit=2}} | {{TOC limit|limit=2}} | ||
<br /> | |||
<br /> | |||
<br /> | |||
<br /> | |||
<br /> | |||
== 3D Structures of Chitinase == | == 3D Structures of Chitinase == | ||
| Line 26: | Line 30: | ||
====Chitinase I binary complex==== | ====Chitinase I binary complex==== | ||
[[3arp]], [[3arq]], [[3arr]], [[3ars]], [[3art]], [[3aru]], [[3arv]], [[3arw]], [[3arx]], [[3ary]], [[3arz]] – VhChi residues 22-597 + inhibitor | [[3arp]], [[3arq]], [[3arr]], [[3ars]], [[3art]], [[3aru]], [[3arv]], [[3arw]], [[3arx]], [[3ary]], [[3arz]] – VhChi residues 22-597 + inhibitor<br /> | ||
[[3as0]], [[3as1]], [[3as2]], [[3as3]] – VhChi residues 22-597 (mutant) + inhibitor | [[3as0]], [[3as1]], [[3as2]], [[3as3]] – VhChi residues 22-597 (mutant) + inhibitor<br /> | ||
[[3b9a]], [[3b9d]] - VhChi residues 22-597 + polysaccharide | [[3b9a]], [[3b9d]] - VhChi residues 22-597 + polysaccharide<br /> | ||
2xvn, 2xuc – AfChi residues 29-307 + inhibitor – Aspergillus fumigatus | [[2xvn]], [[2xuc]] – AfChi residues 29-307 + inhibitor – ''Aspergillus fumigatus''<br /> | ||
3n13, 3n15, 3n17, 3n18 – BcChi (mutant) + NAG | [[3n13]], [[3n15]], [[3n17]], [[3n18]] – BcChi (mutant) + NAG<br /> | ||
3n12 – BcChi + Zn | [[3n12]] – BcChi + Zn<br /> | ||
3n1a - BcChi (mutant) + inhibitor | [[3n1a]] - BcChi (mutant) + inhibitor<br /> | ||
1x6n - SmChi (mutant) + inhibitor | [[1x6n]] - SmChi (mutant) + inhibitor<br /> | ||
1ffq - SmChi + inhibitor | [[1ffq]] - SmChi + inhibitor<br /> | ||
1nh6, 1k9t, 1ffr, 1eib, 1ehn - SmChi (mutant) + polysaccharide | [[1nh6]], [[1k9t]], [[1ffr]], [[1eib]], [[1ehn]] - SmChi (mutant) + polysaccharide<br /> | ||
2wk2, 2wly, 2wlz, 2wm0 – SmChi residues 2-520 + inhibitor | [[2wk2]], [[2wly]], [[2wlz]], [[2wm0]] – SmChi residues 2-520 + inhibitor <br /> | ||
3g6m - BoChi residues 21-426 + caffeine | [[3g6m]] - BoChi residues 21-426 + caffeine<br /> | ||
1waw, 1wb0 – hChi + polypeptide – human | [[1waw]], [[1wb0]] – hChi + polypeptide – human<br /> | ||
1hkk, 1hkm – hChi + inhibitor | [[1hkk]], [[1hkm]] – hChi + inhibitor<br /> | ||
1ll4 - CiChi residues 36-427 + inhibitor | [[1ll4]] - CiChi residues 36-427 + inhibitor<br /> | ||
===Chitinase II=== | ===Chitinase II=== | ||