Peroxisome Proliferator-Activated Receptors: Difference between revisions

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==Natural Ligands==
==Natural Ligands==
[[Image: Linoleic_Acid.png|350px|left|thumb| PPARγ Ligand, Linoleic Acid]]  
[[Image: Linoleic_Acid.png|150px|left|thumb| PPARγ Ligand, Linoleic Acid]]  
<scene name='Peroxisome_Proliferator-Activated_Receptors/Ppar_opening_2/2'>PPAR gamma</scene> binds polyunsaturated fatty acids like linoleic acid, linolenic acid, and  eicosapentaenoic acid at affinities that are in line with serum levels found in the blood. PPARα binds a variety of saturated and unsaturated fatty acids including palmitic acid, oleic acid, linoleic acid, and arachidonic acid.<ref>PMID:1316614</ref> PPARδs ligand selectivity is intermediate between that of the other isotypes and is activated by palmitic acid and a number of eicosanoids.<ref>PMID:7836471</ref>
PPAR gamma binds polyunsaturated fatty acids like linoleic acid, linolenic acid, and  eicosapentaenoic acid at affinities that are in line with serum levels found in the blood. PPARα binds a variety of saturated and unsaturated fatty acids including palmitic acid, oleic acid, linoleic acid, and arachidonic acid.<ref>PMID:1316614</ref> PPARδs ligand selectivity is intermediate between that of the other isotypes and is activated by palmitic acid and a number of eicosanoids.<ref>PMID:7836471</ref>
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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

David Canner, Alexander Berchansky, Michal Harel, Joel L. Sussman