Colicin A: Difference between revisions
No edit summary |
|||
| Line 2: | Line 2: | ||
==Synthesis== | ==Synthesis== | ||
Colicin A is synthesised through a single operon, also containing the colicin A lysis protein encoding gene, <i>Cal</i>, and the ColA [[Colicin Immunity Protein]], [[ | Colicin A is synthesised through a single operon, also containing the colicin A lysis protein encoding gene, <i>Cal</i>, and the ColA [[Colicin Immunity Protein]], [[Colicin_Immunity_Protein]]. The <i>Cal</i> gene is also involved in the expression of the colicin A operon - without the <i>cal</i> gene the amount of colicin A produced decreases<ref> PMID: 9245818 </ref>. The <i>cal</i> gene product is likely to be an activator of colicin A expression, including its own expression. The N terminal region of the <i>cal</i> gene product is particularly involved in the regulation of col A synthesis. A separate, unidentified, product (which may be a heat-shock protein) could also be involved, and complement the <i>cal</i> gene product<ref> PMID: 9245818 </ref>. | ||
The expression of the col A operon provokes a shut-off of chromosomal protein expression, which is due to the expression of the lysis gene. This shut-off gives the col A production a priority over other cellular proteins in their synthesis. | The expression of the col A operon provokes a shut-off of chromosomal protein expression, which is due to the expression of the lysis gene. This shut-off gives the col A production a priority over other cellular proteins in their synthesis. | ||