1aqp: Difference between revisions
New page: left|200px<br /> <applet load="1aqp" size="450" color="white" frame="true" align="right" spinBox="true" caption="1aqp, resolution 2.0Å" /> '''RIBONUCLEASE A COPPE... |
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==About this Structure== | ==About this Structure== | ||
1AQP is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]] with CU as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1AQP OCA]]. | 1AQP is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]] with CU as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5]]. Structure known Active Sites: and CII. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1AQP OCA]]. | ||
==Reference== | ==Reference== | ||
Crystal structures of the copper and nickel complexes of RNase A: metal-induced interprotein interactions and identification of a novel copper binding motif., Balakrishnan R, Ramasubbu N, Varughese KI, Parthasarathy R, Proc Natl Acad Sci U S A. 1997 Sep 2;94(18):9620-5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9275172 9275172] | Crystal structures of the copper and nickel complexes of RNase A: metal-induced interprotein interactions and identification of a novel copper binding motif., Balakrishnan R, Ramasubbu N, Varughese KI, Parthasarathy R, Proc Natl Acad Sci U S A. 1997 Sep 2;94(18):9620-5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9275172 9275172] | ||
[[Category: Bos taurus]] | [[Category: Bos taurus]] | ||
[[Category: Pancreatic ribonuclease]] | |||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Ramasubbu, N.]] | [[Category: Ramasubbu, N.]] | ||
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[[Category: hydrolase (phosphoric diester)]] | [[Category: hydrolase (phosphoric diester)]] | ||
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Revision as of 12:55, 30 October 2007
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RIBONUCLEASE A COPPER COMPLEX
OverviewOverview
We report the crystal structures of the copper and nickel complexes of, RNase A. The overall topology of these two complexes is similar to that of, other RNase A structures. However, there are significant differences in, the mode of binding of copper and nickel. There are two copper ions per, molecule of the protein, but there is only one nickel ion per molecule of, the protein. Significant changes occur in the interprotein interactions as, a result of differences in the coordinating groups at the common binding, site around His-105. Consequently, the copper- and nickel-ion-bound dimers, of RNase A act as nucleation sites for generating different crystal, lattices for the two complexes. A second copper ion is present at an, active site residue His-119 for which all the ligands are from ... [(full description)]
About this StructureAbout this Structure
1AQP is a [Single protein] structure of sequence from [Bos taurus] with CU as [ligand]. Active as [Pancreatic ribonuclease], with EC number [3.1.27.5]. Structure known Active Sites: and CII. Full crystallographic information is available from [OCA].
ReferenceReference
Crystal structures of the copper and nickel complexes of RNase A: metal-induced interprotein interactions and identification of a novel copper binding motif., Balakrishnan R, Ramasubbu N, Varughese KI, Parthasarathy R, Proc Natl Acad Sci U S A. 1997 Sep 2;94(18):9620-5. PMID:9275172
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