Evans sandbox 1: Difference between revisions

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Revision as of 01:59, 8 May 2011 view source Shane Michael Evans (talk \| contribs) 89 edits No edit summary ← Older edit		Latest revision as of 02:04, 8 May 2011 view source Shane Michael Evans (talk \| contribs) 89 edits No edit summary
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	==Regulation==		==Regulation==
	The regulation of E3 kinetically comes through regulation of the entire Pyruvate Dehydrogenase complex. As would be expected, one of the main regulators is the presence of its product, acetyl-CoA as well as NADH. NADH competes with NAD+ with the binding site on E3, ~~therefor~~ regulating the entire pyruvate dehydrogenase complex when NADH is in high concentration.‘<ref>Voet, Donald et al. 2008. Fundamentals of Biochemistry. 3rd ed. p.585</ref>’		The regulation of E3 kinetically comes through regulation of the entire Pyruvate Dehydrogenase complex. As would be expected, one of the main regulators is the presence of its product, acetyl-CoA as well as NADH. NADH competes with NAD+ with the binding site on E3, therefore regulating the entire pyruvate dehydrogenase complex when NADH is in high concentration.‘<ref>Voet, Donald et al. 2008. Fundamentals of Biochemistry. 3rd ed. p.585</ref>’