2cdo: Difference between revisions
New page: left|200px<br /> <applet load="2cdo" size="450" color="white" frame="true" align="right" spinBox="true" caption="2cdo, resolution 1.64Å" /> '''STRUCTURE OF AGARAS... |
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==About this Structure== | ==About this Structure== | ||
2CDO is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Saccharophagus_degradans Saccharophagus degradans]] with CA, CL and EDO as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2CDO OCA]]. | 2CDO is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Saccharophagus_degradans Saccharophagus degradans]] with CA, CL and EDO as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2CDO OCA]]. | ||
==Reference== | ==Reference== | ||
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[[Category: hydrolase]] | [[Category: hydrolase]] | ||
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Revision as of 12:52, 30 October 2007
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STRUCTURE OF AGARASE CARBOHYDRATE BINDING MODULE IN COMPLEX WITH NEOAGAROHEXAOSE
OverviewOverview
Carbohydrate recognition is central to the biological and industrial, exploitation of plant structural polysaccharides. These insoluble polymers, are recalcitrant to microbial degradation, and enzymes that catalyze this, process generally contain non-catalytic carbohydrate binding modules, (CBMs) that potentiate activity by increasing substrate binding. Agarose, a repeat of the disaccharide, 3,6-anhydro-alpha-L-galactose-(1,3)-beta-D-galactopyranose-(1,4), is the, dominant matrix polysaccharide in marine algae, yet the role of CBMs in, the hydrolysis of this important polymer has not previously been explored., Here we show that family 6 CBMs, present in two different beta-agarases, bind specifically to the non-reducing end of agarose chains, recognizing, only the first repeat of the ... [(full description)]
About this StructureAbout this Structure
2CDO is a [Single protein] structure of sequence from [Saccharophagus degradans] with CA, CL and EDO as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
ReferenceReference
Family 6 carbohydrate binding modules in beta-agarases display exquisite selectivity for the non-reducing termini of agarose chains., Henshaw J, Horne-Bitschy A, van Bueren AL, Money VA, Bolam DN, Czjzek M, Ekborg NA, Weiner RM, Hutcheson SW, Davies GJ, Boraston AB, Gilbert HJ, J Biol Chem. 2006 Jun 23;281(25):17099-107. Epub 2006 Apr 6. PMID:16601125
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