Caspase-3/Sandbox: Difference between revisions

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[[Image:IL15-IL15Ra.png]]  
[[Image:IL15-IL15Ra.png]]  
<!-- <Structure load='all.pdb' size='500' frame='true' align='right' {{Button Toggle AnimationOnPause}}<br>




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Aouad, S. M., L. Y. Cohen, et al. (2004). "Caspase-3 is a component of Fas death-inducing signaling complex in lipid rafts and its activity is required for complete caspase-8 activation during Fas-mediated cell death." J Immunol 172(4): 2316-23.
Aouad, S. M., L. Y. Cohen, et al. (2004). "Caspase-3 is a component of Fas death-inducing signaling complex in lipid rafts and its activity is required for complete caspase-8 activation during Fas-mediated cell death." J Immunol 172(4): 2316-23.
Balbi, B., D. R. Moller, et al. (1990). "Increased numbers of T lymphocytes with gamma delta-positive antigen receptors in a subgroup of individuals with pulmonary sarcoidosis." J Clin Invest 85(5): 1353-61.
Boullier, S., M. Cochet, et al. (1995). "CDR3-independent gamma delta V delta 1+ T cell expansion in the peripheral blood of HIV-infected persons." J Immunol 154(3): 1418-31.
Brennan, F. M., M. Londei, et al. (1988). "T cells expressing gamma delta chain receptors in rheumatoid arthritis." J Autoimmun 1(4): 319-26.
Bucht, A., K. Soderstrom, et al. (1992). "T cell receptor diversity and activation markers in the V delta 1 subset of rheumatoid synovial fluid and peripheral blood T lymphocytes." Eur J Immunol 22(2): 567-74.


Budd, R. C. (2001). "Activation-induced cell death." Curr Opin Immunol 13(3): 356-62.
Budd, R. C. (2001). "Activation-induced cell death." Curr Opin Immunol 13(3): 356-62.
Burk, M. R., L. Mori, et al. (1995). "Human V gamma 9-V delta 2 cells are stimulated in a cross-reactive fashion by a variety of phosphorylated metabolites." Eur J Immunol 25(7): 2052-8.
Collins, C., C. Shi, et al. (2008). "Activation of gamma delta T cells by Borrelia burgdorferi is indirect via a TLR- and caspase-dependent pathway." J Immunol 181(4): 2392-8.
Collins, C., J. Wolfe, et al. (2005). "Lyme arthritis synovial gammadelta T cells instruct dendritic cells via fas ligand." J Immunol 175(9): 5656-65.


Degterev, A., M. Boyce, et al. (2003). "A decade of caspases." Oncogene 22(53): 8543-67.
Degterev, A., M. Boyce, et al. (2003). "A decade of caspases." Oncogene 22(53): 8543-67.
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Enari, M., H. Sakahira, et al. (1998). "A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD." Nature 391(6662): 43-50.
Enari, M., H. Sakahira, et al. (1998). "A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD." Nature 391(6662): 43-50.
Hayes, S. M. and P. E. Love (2002). "Distinct structure and signaling potential of the gamma delta TCR complex." Immunity 16(6): 827-38.
Jacobs, M. R. and B. F. Haynes (1992). "Increase in TCR gamma delta T lymphocytes in synovia from rheumatoid arthritis patients with active synovitis." J Clin Immunol 12(2): 130-8.


Kennedy, N. J., T. Kataoka, et al. (1999). "Caspase activation is required for T cell proliferation." J Exp Med 190(12): 1891-6.
Kennedy, N. J., T. Kataoka, et al. (1999). "Caspase activation is required for T cell proliferation." J Exp Med 190(12): 1891-6.
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Misra, R. S., J. Q. Russell, et al. (2007). "Caspase-8 and c-FLIPL associate in lipid rafts with NF-kappaB adaptors during T cell activation." J Biol Chem 282(27): 19365-74.
Misra, R. S., J. Q. Russell, et al. (2007). "Caspase-8 and c-FLIPL associate in lipid rafts with NF-kappaB adaptors during T cell activation." J Biol Chem 282(27): 19365-74.
Poccia, F., S. Boullier, et al. (1996). "Peripheral V gamma 9/V delta 2 T cell deletion and anergy to nonpeptidic mycobacterial antigens in asymptomatic HIV-1-infected persons." J Immunol 157(1): 449-61.
Refaeli, Y., L. Van Parijs, et al. (1998). "Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis." Immunity 8(5): 615-23.
Roessner, K., E. Fikrig, et al. (1994). "Prominent T lymphocyte response to Borrelia burgdorferi from peripheral blood of unexposed donors." Eur J Immunol 24(2): 320-4.
Rust, C., Y. Kooy, et al. (1992). "Phenotypical and functional characterization of small intestinal TcR gamma delta + T cells in coeliac disease." Scand J Immunol 35(4): 459-68.


Sakahira, H., M. Enari, et al. (1998). "Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis." Nature 391(6662): 96-9.
Sakahira, H., M. Enari, et al. (1998). "Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis." Nature 391(6662): 96-9.
Salerno, A. and F. Dieli (1998). "Role of gamma delta T lymphocytes in immune response in humans and mice." Crit Rev Immunol 18(4): 327-57.
Shen, Y., S. Li, et al. (1992). "TCR gamma/delta+ cell subsets in the synovial membranes of patients with rheumatoid arthritis and juvenile rheumatoid arthritis." Scand J Immunol 36(4): 533-40.
Tanaka, Y., C. T. Morita, et al. (1995). "Natural and synthetic non-peptide antigens recognized by human gamma delta T cells." Nature 375(6527): 155-8.
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Van Parijs, L., Y. Refaeli, et al. (1999). "Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fas-mediated activation-induced cell death." Immunity 11(3): 281-8.


Vincent, M. S., K. Roessner, et al. (1996). "Apoptosis of Fashigh CD4+ synovial T cells by borrelia-reactive Fas-ligand(high) gamma delta T cells in Lyme arthritis." J Exp Med 184(6): 2109-17.
Vincent, M. S., K. Roessner, et al. (1996). "Apoptosis of Fashigh CD4+ synovial T cells by borrelia-reactive Fas-ligand(high) gamma delta T cells in Lyme arthritis." J Exp Med 184(6): 2109-17.


Wesselborg, S., O. Janssen, et al. (1993). "Induction of activation-driven death (apoptosis) in activated but not resting peripheral blood T cells." J Immunol 150(10): 4338-45.
Wesselborg, S., O. Janssen, et al. (1993). "Induction of activation-driven death (apoptosis) in activated but not resting peripheral blood T cells." J Immunol 150(10): 4338-45.

Revision as of 20:45, 23 April 2011

Caspases are cysteine aspartic acid proteases that are crucial for the initiation (e.g. caspase-8, -9, -10) and execution (e.g. caspase-3, -6, -7) of apoptosis (Degterev, Boyce et al. 2003) through cleavage of death substrates, such as the BH3 domain-only protein BID by caspase-8 (Li, Zhu et al. 1998) and inhibitor of caspase-activated deoxyribonuclease (ICAD) by caspase-3 (Enari, Sakahira et al. 1998; Sakahira, Enari et al. 1998). It has become appreciated more recently that caspase activity, specifically caspase-8, is also required for T cell growth (Alam, Cohen et al. 1999; Kennedy, Kataoka et al. 1999; Misra, Jelley-Gibbs et al. 2005), and that the location and level of active caspases within cells may be a key determinant of survival or death (Misra, Russell et al. 2007; Koenig, Russell et al. 2008). We have previously observed that murine αβ T cells bearing high levels of caspase activity manifest increased rates of both cell growth and cell death (Dohrman, Russell et al. 2005).

Structure & FunctionStructure & Function

StructureStructure

(Structural Description) (highlighting domains, folds and/or motifs) This is a placeholder text to help you get started in placing a Jmol applet on your page. At any time, click "Show Preview" at the bottom of this page to see how it goes.

Replace the PDB id (use lowercase!) after the STRUCTURE_ and after PDB= to load and display another structure.


PDB ID 2psm

Drag the structure with the mouse to rotate
2psm, resolution 2.19Å ()
Ligands:
Gene: Il15 (Mus musculus), Il15ra (Mus musculus)
Resources: FirstGlance, OCA, PDBsum, RCSB, TOPSAN
Coordinates: save as pdb, mmCIF, xml




FunctionFunction

(Structural insights into its function)

DiseaseDisease

Evolutionarily Related ProteinsEvolutionarily Related Proteins

Proteins + (Links to evolutionarily related proteins) example IL-2, IL-7

Solved StructuresSolved Structures

(Links to available structures) 2PSM 2Z3Q 2Z3R 2ERS

References & NotesReferences & Notes

Alam, A., L. Y. Cohen, et al. (1999). "Early activation of caspases during T lymphocyte stimulation results in selective substrate cleavage in nonapoptotic cells." J Exp Med 190(12): 1879-90.

Aouad, S. M., L. Y. Cohen, et al. (2004). "Caspase-3 is a component of Fas death-inducing signaling complex in lipid rafts and its activity is required for complete caspase-8 activation during Fas-mediated cell death." J Immunol 172(4): 2316-23.

Budd, R. C. (2001). "Activation-induced cell death." Curr Opin Immunol 13(3): 356-62.

Degterev, A., M. Boyce, et al. (2003). "A decade of caspases." Oncogene 22(53): 8543-67.

Dohrman, A., J. Q. Russell, et al. (2005). "Cellular FLIP long form augments caspase activity and death of T cells through heterodimerization with and activation of caspase-8." J Immunol 175(1): 311-8.

Enari, M., H. Sakahira, et al. (1998). "A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD." Nature 391(6662): 43-50.

Kennedy, N. J., T. Kataoka, et al. (1999). "Caspase activation is required for T cell proliferation." J Exp Med 190(12): 1891-6.

Koenig, A., J. Q. Russell, et al. (2008). "Spatial differences in active caspase-8 defines its role in T-cell activation versus cell death." Cell Death Differ 15(11): 1701-11.

Li, H., H. Zhu, et al. (1998). "Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis." Cell 94(4): 491-501.

Misra, R. S., D. M. Jelley-Gibbs, et al. (2005). "Effector CD4+ T cells generate intermediate caspase activity and cleavage of caspase-8 substrates." J Immunol 174(7): 3999-4009.

Misra, R. S., J. Q. Russell, et al. (2007). "Caspase-8 and c-FLIPL associate in lipid rafts with NF-kappaB adaptors during T cell activation." J Biol Chem 282(27): 19365-74.

Sakahira, H., M. Enari, et al. (1998). "Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis." Nature 391(6662): 96-9.

Vincent, M. S., K. Roessner, et al. (1996). "Apoptosis of Fashigh CD4+ synovial T cells by borrelia-reactive Fas-ligand(high) gamma delta T cells in Lyme arthritis." J Exp Med 184(6): 2109-17.

Wesselborg, S., O. Janssen, et al. (1993). "Induction of activation-driven death (apoptosis) in activated but not resting peripheral blood T cells." J Immunol 150(10): 4338-45.

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Phan Thai, Michal Harel
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