ExbD: Difference between revisions
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[[Image:ExbD.jpg|300px|right|thumb| The Structure of ExbD<ref name='Kampfenkel'>PMID: 1644779</ref>]] | |||
ExbD is present in cells only in a complex with [[ExbB]], where is affects the functioning of the TonB complex both in how it responds to the proton motive force as well as its affinity with either the cytoplasmic or outer membrane. <ref>PMID: 12193634</ref> | ExbD is present in cells only in a complex with [[ExbB]], where is affects the functioning of the TonB complex both in how it responds to the proton motive force as well as its affinity with either the cytoplasmic or outer membrane. <ref>PMID: 12193634</ref> | ||
==Structure== | ==Structure== | ||
ExbD has a single transmembrane domain, with residues 1 to 22 on the cytoplasmic side, 23 to 43 within the cytoplasmic membrane and 44 to 141 in the periplasm.<ref name='Kampfenkel'>PMID: 1644779</ref> ExbD has been shown to be approximately 25% identical and 70% similar to the [[TolR]] sequence<ref name='Kampfenkel'>PMID: 1644779</ref>, it can be assumed that these two proteins will have a similar arrangement of their sequences. | |||
ExbD has a single transmembrane domain, with residues 1 to 22 on the cytoplasmic side, 23 to 43 within the cytoplasmic membrane and 44 to 141 in the periplasm.<ref name='Kampfenkel'>PMID: 1644779</ref> | |||
{{STRUCTURE_2pfu | PDB=2pfu | SCENE= Periplasmic_Domain_of_ExbD/Periplasmicdomainexbd/1 }} | {{STRUCTURE_2pfu | PDB=2pfu | SCENE= Periplasmic_Domain_of_ExbD/Periplasmicdomainexbd/1 }} | ||
==Function== It has also been shown that TolR can replace the function of an ExbD mutant just as [[TolQ]] can with ExbB, suggesting an evolutionary link between the two complexes. | |||
== References== | == References== | ||
<references/> | <references/> | ||
Revision as of 19:47, 22 April 2011
ExbD is present in cells only in a complex with ExbB, where is affects the functioning of the TonB complex both in how it responds to the proton motive force as well as its affinity with either the cytoplasmic or outer membrane. [2]
StructureStructure
ExbD has a single transmembrane domain, with residues 1 to 22 on the cytoplasmic side, 23 to 43 within the cytoplasmic membrane and 44 to 141 in the periplasm.[1] ExbD has been shown to be approximately 25% identical and 70% similar to the TolR sequence[1], it can be assumed that these two proteins will have a similar arrangement of their sequences.
==Function== It has also been shown that TolR can replace the function of an ExbD mutant just as TolQ can with ExbB, suggesting an evolutionary link between the two complexes.