Sandbox 111: Difference between revisions
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'''Additional Features''' | '''Additional Features''' | ||
<scene name='Sandbox_111/His37/1'>His37</scene> – His37 has been found to exhibit significant proton selectivity. This suggests that His37 is involved in the opening of the conductive channel. The channel is non-conductive when His37 is not protonated, and conductive when it is in the protonated state. (Pielak) | |||
<scene name='Sandbox_111/Trp41_ring/1'>Trp41</scene> – Replacing Trp41 with a substitute amino acid results in increased channel current in in both directions. As such, the Trp 41 site is important to directional selectivity, in that it regulates the direction of the proton channel flow. This is accomplished in part because it forms a ring that prevents water from entering the channel and reaching the His37, and thus protonating if the pH is high, from the C-terminus. (Pielak) | <scene name='Sandbox_111/Trp41_ring/1'>Trp41</scene> – Replacing Trp41 with a substitute amino acid results in increased channel current in in both directions. As such, the Trp 41 site is important to directional selectivity, in that it regulates the direction of the proton channel flow. This is accomplished in part because it forms a ring that prevents water from entering the channel and reaching the His37, and thus protonating if the pH is high, from the C-terminus. (Pielak) | ||