2of4: Difference between revisions
New page: left|200px<br /> <applet load="2of4" size="450" color="white" frame="true" align="right" spinBox="true" caption="2of4, resolution 2.7Å" /> '''crystal structure of... |
No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:2of4.gif|left|200px]]<br /> | [[Image:2of4.gif|left|200px]]<br /><applet load="2of4" size="350" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="2of4" size=" | |||
caption="2of4, resolution 2.7Å" /> | caption="2of4, resolution 2.7Å" /> | ||
'''crystal structure of furanopyrimidine 1 bound to lck'''<br /> | '''crystal structure of furanopyrimidine 1 bound to lck'''<br /> | ||
| Line 6: | Line 5: | ||
==Overview== | ==Overview== | ||
2,3-Diarylfuro[2,3-b]pyridine-4-amines are a novel class of potent and, selective inhibitors of Lck. The discovery, synthesis, and structure, activity relationships of this series of inhibitors are reported. The most, promising compounds were also profiled to deduce their pharmacokinetic, properties. | 2,3-Diarylfuro[2,3-b]pyridine-4-amines are a novel class of potent and, selective inhibitors of Lck. The discovery, synthesis, and structure, activity relationships of this series of inhibitors are reported. The most, promising compounds were also profiled to deduce their pharmacokinetic, properties. | ||
==About this Structure== | ==About this Structure== | ||
2OF4 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with 979 as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] Full crystallographic information is available from [http:// | 2OF4 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=979:'>979</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OF4 OCA]. | ||
==Reference== | ==Reference== | ||
| Line 23: | Line 19: | ||
[[Category: lck]] | [[Category: lck]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 15:32:16 2008'' | ||
Revision as of 16:32, 23 January 2008
|
crystal structure of furanopyrimidine 1 bound to lck
OverviewOverview
2,3-Diarylfuro[2,3-b]pyridine-4-amines are a novel class of potent and, selective inhibitors of Lck. The discovery, synthesis, and structure, activity relationships of this series of inhibitors are reported. The most, promising compounds were also profiled to deduce their pharmacokinetic, properties.
About this StructureAbout this Structure
2OF4 is a Single protein structure of sequence from Homo sapiens with as ligand. Active as Non-specific protein-tyrosine kinase, with EC number 2.7.10.2 Full crystallographic information is available from OCA.
ReferenceReference
Discovery of novel 2,3-diarylfuro[2,3-b]pyridin-4-amines as potent and selective inhibitors of Lck: Synthesis, SAR, and pharmacokinetic properties., Martin MW, Newcomb J, Nunes JJ, Bemis JE, McGowan DC, White RD, Buchanan JL, Dimauro EF, Boucher C, Faust T, Hsieh F, Huang X, Lee JH, Schneider S, Turci SM, Zhu X, Bioorg Med Chem Lett. 2007 Apr 15;17(8):2299-304. Epub 2007 Jan 24. PMID:17276681
Page seeded by OCA on Wed Jan 23 15:32:16 2008